生白固本冲剂治疗晚期肿瘤患者的疗效观察  

The clinical effect of Shengbai Guben granule in advanced cancer patients

作　　者：曾亚奇[1] 刘维帅[2] 王昆[1,2] ZENG Ya-qi;LIU Wei-shuai;WANG Kun(Department of Nutrition,Tianjin Medical University Cancer Hospital,Tianjin 300060, China;Department of Pain Management, Tianjin Medical University Cancer Hospital, National Clinical Reaserch Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, China)

机构地区：[1]天津医科大学肿瘤医院营养科,天津300060 [2]天津医科大学肿瘤医院疼痛科/国家肿瘤临床医学研究中心/天津市肿瘤防治重点实验室,天津300060

出　　处：《肿瘤代谢与营养电子杂志》2016年第3期174-177,共4页Electronic Journal of Metabolism and Nutrition of Cancer

基　　金：国家临床重点专科建设项目经费资助(2013-544);国家自然科学基金项目(81201065)

摘　　要：目的探讨服用生白固本冲剂能否改善晚期肿瘤患者的营养状况及疲乏程度。方法观察性分析自2015年2月24日至2016年6月18日期间在我院接受疼痛治疗且服用生白固本冲剂大于2周的晚期肿瘤患者共计37例,分别采用BFI-C评分、MFI-20评分、PG-SGA评分以及白蛋白水平、握力、膳食摄入量等指标评价服用生白固本冲剂前后患者营养状况和疲乏程度的改变情况。结果患者治疗前BFI-C综合疲乏程度评分为4.57±2.26,治疗后为2.62±1.93,治疗前后评分改变有统计学差异(P=0.000),同样,患者治疗后BFI-C综合疲乏程度评分明显低于治疗前(P=0.001);患者治疗后MFI-20体力疲乏评分(P=0.001)、脑力疲乏评分(P=0.003)均明显低于治疗前;患者治疗后PG-SGA评分亦明显低于治疗前(10.54 vs 12.17,P=0.001);患者治疗前能量摄入均值为786.49 kcal,治疗后能量摄入均值为1002.70 kcal,治疗前后均值改变有统计学差异(P=0.000)。结论晚期肿瘤患者服用生白固本冲剂能缓解患者疲乏程度,增加患者能量摄入,改善营养状况,但尚需大样本临床试验进一步验证。Objective The aim of this study was to discuss whether Shengbai Guben granule can improve the nutritionalstatus and the degree of fatigue in advanced cancer patients. Methods From February 24, 2015 to June 18, 2016, 37 patients whoreceived pain management and oral Shengbai Guben granule therapy more than 2 weeks in our hospital were observed. The changeof nutritional status and the degree of fatigue were evaluated by BFI-C, MFI-20, PG-SGA, albumin level, grip strength, and dailyintake. Results The mean score of the degree of BFI-C before treatment was 4.57±2.26 and the score was 2.62±1.93 after treatment,the score has significant difference (P=0.001). Similarly, the score of the effect of BFI-C after treatment were significant lower thanpre-treatment (P=0.001). The score of MFI-20 mental fatigue (P=0.001), brain fatigue (P=0.003) after treatment were also lowerthan pre-treatment. The PG-SGA score after treatment was also lower than pre-treatment (10.54 versus 12.17, P=0.001). The averageenergy intake of patients before treatment was 786.49 kcal, the average energy intake was 1002.70 kcal after treatment, and the meanchange before and after treatment was statistically significant (P=0.000). Conclusions Oral Shengbai Guben granule can relief thedegree of fatigue, and increase the energy intake and improve the nutritional status, however, it needs further study.

关 键 词：晚期肿瘤 营养治疗 疲乏 生白固本冲剂 

分 类 号：R730.5[医药卫生—肿瘤] R459.3[医药卫生—临床医学]