丹参川芎嗪注射液对比丹参多酚酸盐注射液治疗脑梗死的临床疗效及药物经济学评价  

Clinical efficacy and pharmacoeconomic evaluation of danshen chuanxiongqin injection versus salvianolate injection for cerebral infarction

作　　者：肖洁[1] 胡明[1] XIAO Jie;HU Ming(West China School of Pharmacy, Sichuan University, Chengdu, 610041, China)

机构地区：[1]四川大学华西药学院,成都610041

出　　处：《中国循证心血管医学杂志》2016年第10期1171-1176,共6页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的评价丹参川芎嗪与丹参多酚酸盐对脑梗死患者的临床疗效及成本效果比。方法检索CBM、CNKI、VIP和万方数据库查找有关丹参川芎嗪和丹参多酚酸盐治疗脑梗死的临床随机对照试验,检索时间截止到2014年11月,按照纳入与排除标准筛选文献,提取资料,以间接Meta分析的方法系统评价两种药物治疗脑梗死的临床疗效;成本仅指直接成本,包括常规治疗、给药、检查以及住院费。结果间接Meta分析结果显示,丹参川芎嗪与丹参多酚酸盐治疗脑梗死的有效率分别为89.25%和85.16%;治疗脑梗死的成本分别是4130.36元和5185.23元;成本效果比分别为46.28和60.89,敏感性分析结果稳定。结论与丹参多酚酸盐注射液相比,在治疗脑梗死方面,丹参川芎嗪注射液可能更具有疗效及经济性优势。Objective To investigate cost-effectiveness ratio and clinical efficacy of danshen chuanxiongqininjection versus Salvianolate injection for cerebral infarction. Methods We searched databases (up to November,2014) including CBM, CNKI, VIP, and Wanfang for the randomized controlled trials (RCTs) of comparison betweendanshen chuanxiongqin injection and Salvianolate injection. Literatures were screened based on inclusion andexclusion criteria, then information were extracted. Clinical efficacy of the two drugs was evaluated by indirectmeta-analysis. Direct cost included the cost of conventional treatment, drug, examination and hospitalizationexpenses. Results Based on result of indirect meta-analysis, the success rates were 89.25% for danshenChuanxiongqin injection and 85.16% for Salvianolate injection, while the costs were 4130.36 and 5185.23 CNY,respectively. The cost-effectiveness ratio of two drugs were 46.28 and 60.89. And the results of sensitivity analysiswere stable. Conclusion Compared to Salvianolate injection, Danshen Chuanxiongqin injection was probably moreeutherapeutic and cost-effective for cerebral infarction.

关 键 词：丹参 川芎嗪 丹参多酚酸盐 脑梗死 间接Meta分析 

分 类 号：R743.33[医药卫生—神经病学与精神病学]