基于中医药古籍的槟榔安全性及风险因素分析  

Safety and Risk Factor Analysis on Arecae Semen Base on Ancient Traditional Chinese Medicine Literatures

作　　者：侯文珍[1] 杨乐[2] 马长华[1] 郭晓昕[2] 任经天[2] 宋海波[2] 逄瑜[2] HOU Wen-zhen;YANG Le;MA Chang-hua;GUO Xiao-xin;REN Jing-tian;SONG Hai-bo;PANG Yu(School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China;Center for Drug Reevaluation, China Food and Drug Administration, Beijing 100045, China)

机构地区：[1]北京中医药大学中药学院,北京100102 [2]国家食品药品监督管理总局药品评价中心,北京100045

出　　处：《中国药物警戒》2016年第10期606-608,共3页Chinese Journal of Pharmacovigilance

基　　金：国家"重大新药创制"科技重大专项(2015ZX09501004-001);中医药行业科研专项(201507004)

摘　　要：中药槟榔Arecae Semen为棕榈科植物槟榔Areca catechu L.的干燥成熟种子,临床应用记载首见于南北朝,历代本草文献对槟榔的基原、功效、毒性、炮制、使用禁忌等多有论述。世界卫生组织国际癌症研究中心认定槟榔为一级致癌物,槟榔安全性问题日益引起社会关注。本文对历代本草中记载的槟榔毒性及用药风险因素进行了归纳分析,提出在安全性研究中应重点关注基原、配伍等对槟榔成分和不良反应的影响,为进一步研究提供线索。Traditional Chinese medicine Arecae Semen is dried seed of Areca catechu L. Its clinical application records were first discovered in literatures of the Northern and Southern dynasty. The origins, efficacy, toxicity, processing and taboos of Arecae Semen have been discussed in many ancient herb literatures. The Arecae Semen was identified as a carcinogen by the International Agency for Research on Cancer(IRAC) , and the safety of Arecae Semen has increasingly attracted attention of the society. In this paper, the authors summarized and analyzed the toxicity and medication risk factors of Arecae Semen recorded in ancient herb literatures, and proposed that more attention shall be paid to the effect of the origins and the compatibility on the components and toxicity of Arecae Semen in safety studies, which provides clues for the further studies.

关 键 词：槟榔 安全性 文献研究 

分 类 号：R95[医药卫生—药学]