胃贲门腺癌p-cadherin表达与临床特征的相关性研究  

Association of p-cadherin Protein Expression with Clinical Pathological Parameters in Carcinoma of Gastric Cardia

作　　者：甘亚平[1] GAN Ya-ping(School of Basic Medicine,Hubei University of Science and Technology ^Xianning Hubei 437100 9China)

机构地区：[1]湖北科技学院基础医学院,湖北咸宁437100

出　　处：《湖北科技学院学报（医学版）》2016年第3期194-196,共3页Journal of Hubei University of Science and Technology(Medical Sciences)

摘　　要：目的通过检测p-钙粘蛋白(p-cadherin)在胃贲门腺癌及癌旁正常组织表达情况,探讨p-cadherin蛋白在胃癌中表达是否与患者年龄、性别、肿瘤大小、组织学类型、临床分期以及淋巴结转移等临床相关病理参数有关联。方法采用免疫组化技术,检测121例胃贲门腺癌及40例相应癌旁正常胃黏膜p-cadherin蛋白表达情况。结果 p-cadherin蛋白在正常胃黏膜组织为阴性表达;在中高分化胃腺癌组织阳性表达较高(22/24,92%),高于低分化腺癌(58/79,73%),与粘液腺癌及印戒细胞癌(5/18,28%)相比有统计学差异(P<0.01);p-cadherin表达与患者性别、年龄、肿瘤大小、临床肿瘤分期、淋巴结转移差异无统计学意义(P>0.05)。结论p-cadherin蛋白的表达与胃贲门腺癌分化程度呈明显相关性。Objective To investigate the expression of p-cadherin protein in gastric cardia adenocarcinoma its correlation with clinical pathological parameters, such as patient age, sex, tumor size, lymph node metastasis,histological type,grade and pTNM stage. Methods Immunohistochemical method was used to detect the expression of p-cadherin protein in 121 cases of gastric cardia adenocarcinoma and 40 cases of adjacent normal gastric mucosa. Results The positive rate of P-cadherin protein expression in well-middle differentiated gastric adenocarcinoma was 9 2 % (22/24) , higher than that in poor differentiated adenocarcinoma ( 7 3 % ) or that in mucinous adenocarcinoma and signet ring cell carcinoma ( 2 8 % ) ,and the differences were statistically significant (P <0.001) . However,P-cadherin protein expression was not correlated with patient sex,age,tumor size,lymph node metastasis and TNM stage(P >0.05). Conclusion The expression P-cadherin protein is correlated with the differentiation degree of gastric cardia adenocarcinoma.

关 键 词：胃腺癌 P-CADHERIN 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]