新型雌激素受体GPR30在非小细胞肺癌中的表达  

Expression of GPR30 in non-small cell lung cancer

作　　者：黄伟 阮姝琴 王善伟[3] Huang Wei;Runn Shuqin;Wang Shanwei(Department o f Thoracic Surgery;Department o f Oncology and Hematology ^Chongqing General Hospital y Chongqing 400013 ,China;Department o f Pathology yXi ctn Medical University ,Shaanxi XiUn 710021 ,China.)

机构地区：[1]重庆市人民医院胸外科,重庆400013 [2]重庆市人民医院肿瘤血液科,重庆400013 [3]西安医学院病理教研室,陕西西安710021

出　　处：《现代肿瘤医学》2016年第14期2208-2211,共4页Journal of Modern Oncology

基　　金：重庆市卫生局医学科研项目(编号:2013-2-111);重庆市渝中区科技计划项目(编号:20130144)

摘　　要：目的:研究GPR30与ERα、ERβ、HER2、HER3在非小细胞肺癌中的表达及相关性,并分析GPR30和ERβ与临床病理特征之间的关系。方法:采用免疫组织化学方法检测60例术后非小细胞肺癌组织样本中GPR30、ERα、ERβ、HER2、HER3的表达。结果:GPR30表达在有淋巴结转移、腺癌、低分化、III期肿瘤中明显高于无淋巴结转移、鳞癌、中高分化、Ⅰ-Ⅱ期肿瘤,差异有统计学意义(P<0.05)。ERβ表达在腺癌中显著高于鳞癌(P<0.05)。GPR30表达与ERβ和HER3呈中度正相关(r=0.607,P=0.000;r=0.510,P=0.000)。结论:GPR30与ERβ或HER2-HER3的信号途径可能存在相关性,共同参与非小细胞肺癌的发生发展。O b je ctiv e : To su d y the e x p n s o n of GPR3 0,E R a ,E R p ,HER/ and HER3 in non - snail cell lungcancer (NSCLC) and the relationship among them. The clinicopathological features of GPR30 and ER(B in NSCLCwere also analyzed. M eth od s: The expression of GPR3 0,ERct,E R (B,HER/ and HER3 in 60 cases of specimens ofNSCLC / te r surge/ were examined using immunohistochemistry method. R esu lts: The expression of GPR30 was obviouslyelevated in NSCLC tissue with lymphatic metastasis compared with in tissue without lymphatic metastasis, andthe differences were statistically significant. Expressions of GPR30 were significantly different in TNM stage, pathologictype and tissue differentiation ( P < 0.05). Expression of ER(B in adenocarcinoma was increased than in squamouscell carcinoma ( P < 0. 05 ). Apositive correlation between GPR30 and ERp or HER3 were disclosed ( = 0. 607, P =0. 000 ; r = 0. 5 10, P = 0. 000) . Conclusion : The interaction bet-ween GPR30 and ERp or HER/ - HER3 signal transductionpathways may be involved in the development of NSCLC.

关 键 词：雌激素受体 GPR30 非小细胞肺癌 

分 类 号：R734.2[医药卫生—肿瘤]