75岁以上老年食管癌适形放疗疗效分析  

Efficacy of three-dimensional conformal radiotherapy(3DCRT) in patients over 75 years old with esophageal carcinoma

作　　者：汪超[1] 彭万仁[1] 汤晓伟[1] 肖鑫[1] 刘克[1] Wang Chao;Peng Wanren;Tang Xiaowei;Xiao Xin;Liu Ke(Department o f Oncology yChaohu Hospital o f Anhui Medical University ,Anhui Chaohu 2 3 2 2 2 ,China.)

机构地区：[1]安徽医科大学附属巢湖医院肿瘤内科,安徽巢湖238000

出　　处：《现代肿瘤医学》2016年第14期2240-2243,共4页Journal of Modern Oncology

摘　　要：目的:探讨三维适形放疗对75岁以上老年食管癌患者的疗效及毒副反应。方法:回顾性分析我院自2009年1月至2012年7月接受根治性三维适形放疗(three-dimensional conformal radiotherapy,3DCRT)和常规分割放疗(conventional fraction radiotherapy,CFRT)的112例75岁以上老年食管鳞癌患者临床资料,对比分析两组近期有效率,1、2年局部控制率及生存率,毒副反应。结果:3DCRT组、CFRT组近期有效率分别为86.5%和68.8%,1年局部控制率分别为76.1%和53.3%。2年局部控制率分别为46.3%和24.4%,1年生存率分别为79.1%和64.4%,2年生存率分别为49.3%和28.9%。治疗毒副反应相似。结论:75岁以上老年食管癌患者行三维适形放疗疗效优于常规分割放疗,不良反应可耐受。Objective: To analyze the efficacy and the toxicity of esophageal carcinoma treated with three - dimen-sional conformal radiotherapy. Methods:From January 2009 to June 2012,112 patients over 75 years old with esopha-geal carcinoma treated with three - dimensional conformal radiotherapy(3DCRT) and conventional fraction radiothera- py(CFRT) were retrospectively analyzed. The short-term effects, acute side radioative effects,1,2 -year local con-trol rates and the survival rates were evaluated. Results:The short - term effects of 3DCRT and CFRT were 88. 0% and 73.4%. The 1 - year local control rates were70. 1% and 56. 7%,the 2 - year local control rates were 32. 8% and 25. 4%. The 1 - year overall survival rates were 58.2% and 44. 8%,the 2 - year overall survival rates were 35. 8% and 25. 3% . The acute side radioative effects in the two groups were similar. Conclusion:For patients o-ver 75 years old with esophageal carcinoma, the efficacy of three - dimensional conformal radiotherapy is superior to conventional fraction radiotherapy and the toxicities can be tolerated.

关 键 词：老年性食管癌 放疗 常规分割 三维适形 预后 

分 类 号：R735.1[医药卫生—肿瘤]