HPV分型研究在宫颈癌筛查中的意义  

The significance of HPV genotypes in cervical cancer screening

作　　者：张静[1] 刘晓英[1] 甘露[1] 刘波[1] Zhang Jing;Liu Xiaoying;Gan Lu;Liu Bo(Shaanxi Province People’s Hospital’Shaanxi Xi'an 1 1 3 0 6 ,China.)

机构地区：[1]陕西省人民医院,陕西西安710068

出　　处：《现代肿瘤医学》2016年第14期2293-2296,共4页Journal of Modern Oncology

基　　金：陕西省自然科学基础研究计划项目(编号:2014JQ2-8055)

摘　　要：目的:探讨HPV分型流行病学特征及其与宫颈癌前病变的关系。方法:选择陕西省人民医院2014年1月-2014年12月在妇科门诊就诊、有性生活史并行宫颈液基细胞学(TCT)检查的患者10 885例,其中2 677例患者同时行宫颈感染人乳头瘤病毒(HPV)分型筛查。结果:TCT异常率(≥ASCUS)7.6%;HPV感染率34.8%,其中高危型HPV占76.93%,低危型HPV占23.93%;混合感染(2种以上HPV亚型感染)占20.28%,高危型HPV感染主要型别为HPV16、HPV52、HPV58;低危型HPV感染主要型别为HPV6、HPV11、HPV43;未发现HPV26、73、83型阳性病例;≤29岁及≥50岁年龄段为HPV感染及TCT异常的高峰年龄段;HPV感染率随着细胞学诊断级别及病理学诊断级别的升高而显著上升。结论:不同年龄段HPV分型感染率及TCT异常率不同,HPV感染率与宫颈病变严重程度呈显著正相关。Objective:To study the epidemiological characteristics of different genotypes of human papillomavirus (HPV) and their relationship with cervical precancerous lesions. Methods: A total of 10 885 patients who had sex life and requested cervical screening were enrolled from the outpatient section of Gynec in the study. All the patients un-derwent cervical cytology tests (TCT) , among them 2 677 patients had cervical HPV subtype screening. Results :TCT -positive rate( ^ASCUS) was 7. 6%. HPV infection rate was 34.8% , among which 76. 93% were high - risk, 23.93% were low - risk, and 20. 28% were mixed infection (infected from two or more HPV subtypes) . The high- risk HPV infections were mainly caused by HPV16,HPV52 and HPV58 while the low - risk infections were mainly caused by HPV6,HPV11 and HPV43. No infection was found caused by HPV26,HPV73 or HPV83. ^29 years and ^ 50 years were peak ages of both HPV infection and cytology abnormality. HPV infection rates increased significantly as the deterioration of cytological and pathology diagnosis. Conclusion : HPV infection rate and TCT positive rate varied among different ages. HPV infection rate was significantly correlated with the severity of cervical lesion.

关 键 词：人乳头瘤状病毒分型 宫颈液基细胞学 宫颈癌 

分 类 号：R737.33[医药卫生—肿瘤]