非小细胞肺癌患者表皮生长因子受体突变与血清癌胚抗原和糖类抗原检测的关系  

The relationship between epidermal growth factor receptor(EGFR) gene mutation and serum carcinoembryonic antigen and carbohydrate antigen in patients with NSCLC

作　　者：杨福利[1] 王继松[1] 牟坤[1] 黄振宇[1] 施明亮[1] Yang Fuli;Wang Jisong;Mu Kun;Huang Zhenyu;Shi Mingliang(Department of Oncology ,Laiwu City Peoples Hospital, Laiwu 27H99, China)

机构地区：[1]山东莱芜市人民医院肿瘤科,271199

出　　处：《中国临床保健杂志》2016年第2期132-134,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的研究非小细胞肺癌(NSCLC)患者表皮生长因子受体(EGFR)基因突变与血清癌胚抗原(CEA)、糖类抗原(CA125、CA199)的关系,研究其对靶向治疗的价值。方法选择非小细胞肺癌患者193例,术前行血清CEA、CA125、CA199检测作为备用数据,术后对标本行EGFR检测,分析CEA、CA125、CA199与EGFR基因突变的关系及临床意义。结果全组患者中发生EGFR基因突变者共83例,基因突变率为43.0%;EGFR基因突变在女性、非吸烟及腺癌患者多见(P<0.05);EGFR基因突变与CEA值呈正相关(P<0.05);EGFR与CA125、CA199无相关性(P>0.05)。结论非小细胞肺癌EGFR基因突变在女性、非吸烟及腺癌患者中多见,其突变与血清CEA水平升高有关。Objective To investigate the relationship between epidermal growth factor receptor ( EGFR) genemutation and carcino embryonie antigen (CEA) , carbohydrate antigen ( CA125, CA199 ) in patients with none small celllung cancer (NSCLC) and explore prognostic values. Method 193 cases with NSCLC from January 2012 to January2014 in the Laiwu People's Hospital were selected, the preoperative serum levels of CEA,CA125,and the relationship between the CEA,CA125,CA199 and EGFR gene mutation were analyzed. Result EGFR genemutations were detected in 83 cases (43. 0% ) ; EGFR gene mutation were more commonly found in female, non-smokesand adenocarcinoma ( P < 0. 05 ) ; EGFR gene mutation was positive correlated with CEA level( P < 0. 05 ) ; while therewere no correlation between EGFRand CA125/CA199(P >0. 05) . Conclusion EGFR gene mutation is more commonlyfound in female, non-smokers and adenocarcinoma, which is related to the increased

关 键 词：癌 非小细胞肺 受体 表皮生长因子 癌胚抗原 CA-19-9抗原 CA-125抗原 

分 类 号：R734.2[医药卫生—肿瘤]