去痛片溶出度测定方法的研究  

Study on the determination method of dissolution rate of compound aminopyrine phenacetin tablets

作　　者：赵海欣 袁步娟 Zhao Haixin;Yuan Bujuan(Department of Pharmacy,the People's Hospital of Jianhu County 224700;Institute for Drug Control of Yancheng City 224002)

机构地区：[1]建湖县人民医院药学部,24700 [2]盐城市药品检验所,224002

出　　处：《中国社区医师》2016年第35期22-23,25,共3页Chinese Community Doctors

摘　　要：目的:建立去痛片溶出度的测定方法。方法:采用《中国药典》2010年版附录溶出度测定法第二法。按药典桨法,采用智能溶出试验仪,以水为溶出介质,测定溶出度。结果:去痛片中咖啡因、非那西丁、苯巴比妥、氨基比林的平均回收率分别为100.1%、100.4%、99.8%和100.0%,样品溶出度均一性好。在35 min时采样测定,4个组分溶出度均达到70%。结论:本方法准确、方便,结果满意,适用于去痛片中四种成分的溶出度的测定。Objective:To explore the determination method of dissolution rate of compound aminopyrine phenacetin tablets.Methods:We used the second method of determination method of dissolution rate of "Chinese Pharmacopoeia" in 2010.Accordingto the paddle method in Chinese Pharmacopoeia,we measured the dissolution rate by the intelligent dissolution test instrument,and took the water as the dissolution medium.Results:In compound aminopyrine phenacetin tablets,the average recovery rate ofcaffeine,phenacetin,phenobarbital,aminopyrine was 100.1% ,100.4% ,99.8% and 100% respectively,and sample dissolutionuniformity was good.For the sampling measurement in 35 minutes,the dissolution rate of the 4 groups all reached 70%.Conclusion:The method was accurate and convenient,and the results were satisfactory,which was suitable for the dissolution determination offour components in compound aminopyrine phenacetin tablets.

关 键 词：去痛片 氨基比林 非那西丁 咖啡因 苯巴比妥 溶出度 

分 类 号：R927.2[医药卫生—药学]