PET-CT在晚期上颌骨恶性肿瘤放射性粒子植入治疗中的应用价值研究  

Preliminary investigation of PET-CT applied in malignant maxillary cancer patients undergoing radioactive seeds implantation

作　　者：王兴[1] 孟箭[1] 顾倩平[1] 张杰[1] Wang Xing;Meng Jian;Gu Qianping;Zhang Jie(Department of Stomatology, Xuzhou Central Hospital , Xuzhou 221009, China)

机构地区：[1]徐州市中心医院口腔科,徐州221009

出　　处：《中华介入放射学电子杂志》2016年第3期142-145,共4页Chinese Journal of Interventional Radiology：electronic edition

基　　金：江苏省"六大人才高峰"D类项目(2012-WS-099);徐州市医学创新(技术攻关)领军人才项目(XWCX201604)

摘　　要：目的:探讨正电子发射计算机断层显像(PET-CT)引导靶区定位技术在^(125)I放射性粒子植入治疗晚期上颌骨恶性肿瘤中的应用价值。方法:选取11例上颌骨恶性肿瘤患者进行^(125)I放射性粒子植入植入前分别予以CT及PET-CT检查,将扫描数据导入近距离治疗计划系统,标记肿瘤靶区,对不同靶区设计所得的靶区体积进行比较。基于PET-CT扫描数据进行放射性粒子植入治疗。结果:PET-CT勾画的生物靶区(BTV)体积和CT勾画的大体肿瘤区(GTV)体积分别为(35.21±7.8)cm^3和(42.17±9.32)cm^3,BTV小于GTV,差异有统计学意义(t=7.25,P<0.001)。局部未见肿瘤复发,无明显并发症。结论:利用PET-CT定位的上颌骨恶性肿瘤靶区可提高放射性粒子植入治疗的精确性,具有较好的可行性与可靠性。Objective: To investigate the value of PET-CT guided target localization technique in radioactive iodine 125 seeds implantation for treating malignant maxillary cancer. Methods: Eleven patients diagnosed with maxillary malignant tumors underwent PET-CT scans and CT scans. The three-dimensional tumor imaging generated data was converted into DICOM format by the treatment planning system. Virtual implantation was also manipulated according to the three-dimensional position of the tumor. Gross tumor volume and matched peripheral dose were compared in different imaging methods. Results: The volumes of BTV and GTV byPET-CT were (35.21±7.8) cm3 and (42.17±9.32) cm3, respectively. Compared to CT imaging, the volumes and dose were significantly smaller (t=7.25, P<0.05). No tumors recurred and there were no severe complications.Conclusions: PET-CT is a feasible and reliable method for the diagnosis and treatment of maxillary malignant tumor, and it can significantly improve the accuracy of iodine 125s eeds implantation.

关 键 词：上颌骨肿瘤 正电子发射断层显像术 近距离放疗 125I放射性粒子植入 治疗计划系统 

分 类 号：R739.82[医药卫生—肿瘤]