紫外光谱法研究喷昔洛韦与DNA的相互作用  

Interaction of Ultraviolet Spectroscopy Study of Penciclovir and DNA

作　　者：王晓霞[1] 郭贵宝[1] 王正德[1] 马力通[1] 闫慧[1] 海波[1] 刘云颖[1] 白宇辰[1] WANG Xiaoxia;GUO Guibao;WANG Zhengde;MA Litong;YAN Hui;HAI Bo;LIU Yunying;BAI Yuchen(College of Chemistry and Chemical Engineering, Inner Mongolia University of Science and Technology, Baotou 014010, China)

机构地区：[1]内蒙古科技大学化学与化工学院,内蒙古包头014010

出　　处：《化工技术与开发》2016年第12期1-4,共4页Technology & Development of Chemical Industry

基　　金：国家自然科学基金(21463016);内蒙古自然科学基金(2013MS0209);内蒙古高等学校科学研究项目(NJZZ14160);内蒙古科技大学创新基金资助项目(2012NCL034)

摘　　要：本文采用紫外光谱法研究了喷昔洛韦与DNA相互作用的光谱特性。结果表明,DNA的加入使喷昔洛韦的紫外光谱产生增色、蓝移的现象;喷昔洛韦与DNA之间的作用主要是嵌插作用,它们之间的结合常数K=3.14×10~2L·mol^(-1)。The spectral properties of penciclovir and DNA by UV spectra technique was studied. The results showed that the addition of DNA made the ultraviolet spectrum of penciclovir produce color, blue shift phenomenon. Between the penciclovir and DNA role was the intercalation. The binding constant between them was K =3.14×102 L/mol.

关 键 词：喷昔洛韦 DNA 紫外吸收光谱 

分 类 号：TQ463[化学工程—制药化工] R914.5[医药卫生—药物化学]