术前中性粒细胞与淋巴细胞比值对可切除性胰腺癌患者预后的影响  

Predictive value of preoperative neutrophil to lymphocyte ratio in prognosis of pancreatic cancer patients undergoing radical surgery

作　　者：程俊峰[1] 俞世安[1] 郑樟栋[1] CHEN Junfeng;YU Shian;ZHENG Zhangdong(Department of Hepatopancreatobiliary Surgry,Jinhua Hospital of Zhejiang University,Jinhua 321000,China)

机构地区：[1]金华市中心医院(浙江大学金华医院)肝胆胰外科一区,321000

出　　处：《浙江医学》2017年第2期109-111,114,共4页Zhejiang Medical Journal

摘　　要：目的探讨术前外周血中性粒细胞与淋巴细胞比值(NLR)对可切除性胰腺癌患者预后的预测价值。方法回顾性分析接受胰腺癌根治术64例患者的临床资料,根据ROC曲线选取特异度和灵敏度最大的NLR为截点,将患者分为高、低NLR两组;分析患者预后的影响因素,比较两组患者术后1年生存率。结果根据ROC曲线,选取3.06为截点。单因素分析结果显示,患者年龄、肿瘤T、N分期、NLR均是预后的影响因素(均P<0.05),而多因素分析结果显示高NLR是患者预后的独立影响因素。高NLR组患者和低NLR组患者术后1年生存率分别为66.2%、77.5%,两组比较差异有统计学意义(P<0.05)。结论对接受根治性手术的胰腺癌患者,术前高NLR是预后不良的独立影响因素。Objective To evaluate the application of preoperative neutrophil-lymphocyte ratio(NLR)for the prognosis ofpancreatic cancer patients undergoing radical resection.Methods The clinical data of64patients who underwent radicalresection for pancreatic cancer were analyzed retrospectively.The patients were divided into high and low NLR groupsaccording to the cut-off value of NLR based on receiver operating characteristic curve(ROC).The clinic pathological data andone-year survival rate were compared between two groups.Results According to ROC analysis3.06was chosen as cut-offvalue.Univariate analysis revealed that age,clinical stage and NLR level were associated with survival of patients.Multivariateanalysis showed that the high NLR value was independent prognostic factor(P<0.05).The1year survival rate of higher NLRgroup and lower NLR group was66.2%and77.5%,respectively(P<0.05).Conclusion A high preoperative NLR is a risk factorfor poorer prognosis of pancreatic cancer patient after radical resection.

关 键 词：胰腺癌 中性粒细胞与淋巴细胞比值 预后 

分 类 号：R735.9[医药卫生—肿瘤]