盐酸多奈哌齐联合认知行为疗法对轻度认知功能障碍患者的临床疗效  

Clinical curative effect of donepezil hydrochloride combined with cognitive behavior therapy on patients with mild cognitive impairment

作　　者：龚恒芬[1] 黄瑛[1] 金莹[1] 孙喜蓉[1] 瞿家兴 黄娟[1] 奚玥[1] 陆伟[1] 赵楠[1] Gong Hengfen;Huang Ying;Jin Ying;Sun Xirong;Qu Jiaxing;Huang Juan;Xi Yue;Lu Wei;Zhao Nan(Mental Health Center of Pudong New Area,Shanghai City 200124)

机构地区：[1]上海市浦东新区精神卫生中心,200124

出　　处：《中国社区医师》2017年第2期29-30,共2页Chinese Community Doctors

基　　金：上海市浦东新区卫生系统优秀青年医学人才培养计划;课题编号:PWRq2014-29~~

摘　　要：目的:探讨盐酸多奈哌齐联合认知行为疗法对轻度认知功能障碍的疗效。方法:收治轻度认知功能障碍患者70例,随机分为西药组与联合组各35例,西药组给予盐酸多奈哌齐口服,联合组在口服多奈哌齐的基础上,采用认知行为疗法干预,疗程均12周。结果:治疗后8周与12周,联合组MMSE评分显著高于西药组(P<0.05),联合组Mo CA评分显著低于西药组(P<0.05)。结论:盐酸多奈哌齐联合认知行为疗法相较于单纯的西药治疗,能更好地改善轻度认知功能障碍患者的精神状态与认知功能,有利于患者后期的病情恢复,提高生活质量。Objective:To investigate the efficacy of donepezil combined with cognitive behavioral therapy on mild cognitive impairment.Methods:70 patients with mild cognitive impairment were selected.They were randomly divided into the westernmedicine group and the combined group with 35 cases in each group.The western medicine group were given oral donepezilhydrochloride.The combined group used cognitive behavioral therapy intervention on the basis of oral donepezil.They were treatedfor 12 weeks.Results:After 8 weeks and 12 weeks of the treatment,the MMSE score of the combined group was significantly higherthan that of the western medicine group(P<0.05),and the MoCA score of the combined group was significantly lower than that ofthe western medicine group(P<0.05).Conclusion:Donepezil hydrochloride combined with cognitive behavioral therapy compared with simple western medicine treatment,the former can improve the mental state of patients with mild cognitive impairment and cognitive function.It is beneficial to the patients with late disease recovery,and it can improve the quality of life.

关 键 词：盐酸多奈哌齐 认知行为疗法 功能障碍 

分 类 号：R749.1[医药卫生—神经病学与精神病学]