介入技术联合药物治疗缺血性脑血管疾病的临床研究  

Clinical study of interventional technique combined with drugs in the treatment of ischemic cerebrovascular disease

作　　者：熊峰 Xiong Feng(Department of Neurology,Zhuzhou City Central Hospital 412000)

机构地区：[1]株洲市中心医院神经内科,412000

出　　处：《中国社区医师》2017年第3期11-12,共2页Chinese Community Doctors

摘　　要：目的:探讨介入技术联合药物治疗缺血性脑血管疾病的临床效果。方法:将66例缺血性脑血管疾病患者随机分为两组,各33例。两组均给予介入治疗,对照组给予0.9%氯化钠溶液100 m L静脉滴注,观察组给予丁苯酚氯化钠注射液25 mg静脉滴注。比较两组患者术前、术后即刻、术后3 d血浆NO、ET-1及vWF水平。结果:术后3 d观察组NO高于对照组(P<0.05),ET-1、vWF低于对照组(P<0.05);术后即刻观察组NO低于术前(P<0.05),ET-1、vWF高于术前(P<0.05);术后3 d观察组NO、vWF均恢复到术前水平(P>0.05),ET-1仍高于术前(P<0.05)。结论:介入技术联合丁苯酚氯化钠注射液可显著降低介入手术对缺血性脑血管疾病患者血管内皮功能的损伤程度,疗效尤佳。Objective:To explore the clinical effect of interventional technique combined with drugs in the treatment of ischemic cerebrovascular disease.Methods:66 patients with ischemic cerebrovascular disease were randomly divided into two groups with 33 cases in each.The two groups were given interventional therapy.The control group was given 0.9% sodium chloride solution 100 mL intravenous infusion.The observation group was given butyl phenol sodium chloride injection 25 mg intravenous infusion.The plasma NO,ET-1 and vWF levels of two groups were compared before operation,immediately after operation,and 3 days afteroperation.Results:3 days after operation,the NO of the observation group was higher than that of the control group(P<0.05);theET-1,vWF were lower than those of the control group(P<0.05).Immediately after operation,the NO of the observation group waslower than that before operation(P<0.05);the ET-1,vWF were higher than that before operation(P<0.05).3 days after operation,the NO,vWF of the observation group were returned to the preoperative levels(P>0.05);the ET-1 was still higher than that beforeoperation(P<0.05).Conclusion:Interventional technique combined with butyl phenol sodium chloride injection can significantly reduce the damage degree of interventional operation on the vascular endothelial function in patients with ischemic cerebrovascular disease,and the curative effect is a plus.

关 键 词：介入技术 丁苯酚氯化钠注射液 缺血性脑血管疾病 血管内皮功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]