多奈哌齐联合尼莫地平治疗血管性痴呆的疗效观察  

Observation on the curative effect of donepezil combined with nimodipine in the treatment of vascular dementia

作　　者：罗晓静[1] 白良[1] 杨成蓉[1] Luo Xiaojing;Bai Liang;Yang Chengrong(Department of Neurology,the People's Hospital of Ya'an City,Sichuan Province 625000)

机构地区：[1]四川省雅安市人民医院神经内科,625000

出　　处：《中国社区医师》2017年第3期73-73,75,共2页Chinese Community Doctors

摘　　要：目的:观察多奈哌齐与尼莫地平联合治疗血管性痴呆患者的效果。方法:收治血管性痴呆患者128例,随机分两组。对照组给予多奈哌齐治疗,试验组给予多奈哌齐与尼莫地平联合治疗。比较两组临床疗效。结果:试验组的MMSE和ADL评分均显著高于对照组,差异有统计学意义(P<0.05)。试验组的临床总有效率显著高于对照组,差异有统计学意义(P<0.01)。结论:临床治疗血管性痴呆患者,多奈哌齐与尼莫地平联合治疗可显著改善患者的认知功能障碍,减少不良反应发生。Objective:To investigate the mode of treatment and the therapeutic effect of donepezil and nimodipine in the treatment of patients with vascular dementia.Methods:128 cases patients with vascular dementia were selected.They were randomly divided into the two groups.The control group was given donepezil treatment,and the experimental group was given donepezil combined with nimodipine treatment.The clinical effect was compared between groups.Results:The MMSE and ADL scores of theexperimental group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).The clinical total effective rate of the experimental group was significantly higher than that of the control group,and the difference was statistically significant(P<0.01).Conclusion:During the process of clinical treatment of patients with vascular dementia,donepezil and nimodipine combination treatment can significantly improve the cognitive impairment in patients,reduce the incidence of adverse reactions.

关 键 词：血管性痴呆 多奈哌齐 尼莫地平 

分 类 号：R749.13[医药卫生—神经病学与精神病学]