无功能性垂体瘤病人头痛特点的分析  

CLINICAL CHARACTERISTICS OF HEADACHE IN NONFUNCTIONING PITUITARY ADENOMAS

作　　者：于斌[1] 王云珍[1] 胡正芳[1] 罗芳[1] YU Bin;WANG Yun-Zhen;HU Zheng-Fang;LUO Fang(Department of Anesthesiology and Pain Management, Beijing Tiantan Hospital, Beijing 100050,China)

机构地区：[1]首都医科大学附属北京天坛医院麻醉疼痛科,北京100050

出　　处：《中国疼痛医学杂志》2017年第2期101-105,共5页Chinese Journal of Pain Medicine

基　　金：北京市卫生系统高层次人才(学科骨干)项目(2014-3-035)

摘　　要：目的:探讨无功能性垂体瘤病人头痛的发病率、特点及引起头痛的危险因素,为临床医生更好地诊断、治疗提供理论依据。方法:前瞻性地观察130例内分泌检查正常、经鼻蝶垂体瘤切除术病人头痛的特点,分析头痛可能的原因。结果:102例术后病理诊断为无功能性垂体瘤的病人纳入研究。术前头痛的发病率为52.0%,92.5%的头痛病人属于继发性头痛,64.2%病人头痛发作部位符合三叉神经分布区域,86.8%的病人类似偏头痛样头痛。女性、有原发性头痛家族史及海绵窦侵袭是无功能性垂体瘤病人发生头痛的危险因素(P<0.05),病人的年龄、肿瘤的大小、吸烟与否与头痛的发生无相关性(P>0.05)。结论:无功能性垂体瘤病人头痛发病率较高,大多数属于继发性头痛,临床表现类似于偏头痛。女性、有慢性头痛家族史及侵袭海绵窦的无功能性垂体瘤病人更易罹患头痛。Objective:To investigate the prevalence,clinical characteristics and risk factors of headachein the nonfunctioning pituitary adenoma(NFPA)in patients with normal endocrine activity and to providethe theoretical basis for the clinical diagnosis and treatments.Methods:One hundred and thirty patientswith normal endocrine activity preoperatively who were primarily diagnosed as NFPA were prospectivelyinvestigated for the characteristics of headache.The possible risk factors were analyzed.Results:Onehundred and two patients who were confirmed as NFPA postoperatively were enrolled in this study.Thepreoperative prevalence of headache in NFPA was52.0%,of which92.5%of the headache were secondaryheadache,64.2%had headache involving trigeminal territory,and86.8%showed migraine-like headache.Female patients,a family history of primary headache and cavernous sinus invasions were risk factors forheadache in NFPA(P<0.05).Age of patients,volume size of tumor and smoking had no correlations withincidence of headache(P>0.05).Conclusions:The incidence of headache in patients with NFPA was high,of which most were secondary headache.Its clinical manifestations were similar to migraine.Female patientswith a family history of primary headache and cavernous sinus invasion were more likely to suffer headache.

关 键 词：垂体瘤 无功能性垂体瘤 头痛 继发性头痛 偏头痛 

分 类 号：R736.4[医药卫生—肿瘤]