紫杉醇联合顺铂腹腔和静脉双途径治疗晚期卵巢癌的临床效果分析  

Analysis on clinical effect of taxol combined with cis-platinum by abdominal cavity and vein dual approaches for treatment of advanced ovarian cancer

作　　者：高嘉蔚 叶松 GAO Jia-wei;YE Song(Fushun City Fourth Hospital, Fushun 113123, China)

机构地区：[1]抚顺市第四医院,113123

出　　处：《中国现代药物应用》2017年第2期88-90,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析紫杉醇联合顺铂腹腔和静脉双途径治疗晚期卵巢癌的临床效果。方法 74例晚期卵巢癌患者,依据治疗方法不同分为观察组和对照组,各37例。对照组选择紫杉醇进行治疗,观察组在对照组基础上联合顺铂腹腔和静脉双途径进行治疗,对两组患者的临床治疗效果进行对比。结果观察组患者完全缓解(CR)21例(56.76%),部分缓解(PR)10例(27.03%),稳定(SD)4例(10.81%),进展(PD)2例(5.41%),治疗有效率为94.59%;对照组患者CR 14例(37.84%),PR 8例(21.62%),SD 5例(13.51%),PD 10例(27.03%),治疗有效率为72.97%;两组有效率比较差异有统计学意义(χ2=6.3656,P<0.05)。观察组患者腹水控制有效患者30例(81.08%),腹水控制无效患者7例(18.92%);对照组患者腹水控制有效患者22例(59.46%),腹水控制无效患者15例(40.54%);两组腹水控制有效率比较差异有统计学意义(χ2=4.1399,P<0.05)。观察组糖类抗原125(CA125)水平控制有效32例(86.49%),CA125水平控制无效5例(13.51%);对照组CA125水平控制有效24例(64.86%),CA125水平控制无效13例(35.14%);两组CA125水平控制有效率比较差异有统计学意义(χ2=4.6984,P<0.05)。结论晚期卵巢癌在临床治疗中选择紫杉醇联合顺铂腹腔和静脉双途径方法 ,治疗效果较为理想,具有临床应用价值。Objective To analyze the clinical effect of taxol combined with cis-platinum by abdominalc avity and vein dual approaches for treatment of advanced ovarian cancer. Methods A total of 74 advanced ovarian cancer patients were divided by different treatment methods into observation group and control group, with 37 cases in each group. The control group receive taxol for treatment, and the observation group received taxol combined with cis-platinum by abdominal cavity and vein dual approaches for treatment. Clinical curative effect was compared in two groups. Results The observation group had 21 complete remission (CR) cases (56.76%), 10 partial remission (PR) cases (27.03%), 4 stable disease (SD) cases (10.81%), 2 progress disease (PD) cases (5.41%), with treatment effective rate as 94.59%. The control group had 14 CR cases (37.84%), 8 PR cases (21.62%), 5 SDcases (13.51%), 10 PD cases (27.03%), with treatment effective rate as 72.97%. There was statistically significantdifference in treatment effective rate in two groups (χ2=6.3656, P<0.05). The observation group had 30 effective ascitescontrol cases (81.08%), and 7 ineffective ascites control cases (18.92%), while the control group had 22 effectiveascites control cases (59.46%) and 15 ineffective ascites control cases (40.54%). There was statistically significantdifference in effective rate of ascites control in two groups (χ2=4.1399, P<0.05). The observation group had 32effective carbohydrate antigen 125 (CA125) control cases (86.49%) and 5 ineffective CA125 control cases (13.51%),while the control group had 24 effective CA125 control cases (64.86%) and 13 ineffective CA125 control cases (35.14%). There was statistically significant difference in effective rate of CA125 control in two groups (χ2=4.6984,P<0.05). Conclusion Taxol combined with cis-platinum by abdominal cavity and vein dual approaches shows perfect curative effect for treatment of advanced ovarian cancer, and it contains clinical application value.

关 键 词：紫杉醇 顺铂 晚期卵巢癌 治疗效果 

分 类 号：R737.31[医药卫生—肿瘤]