新辅助化疗对胃癌手术并发症的影响研究  

Study on effect of neoadjuvant chemotherapy for complications of gastric cancer surgery

作　　者：杨亚冰[1] YANG Yabing(Department of Oncology, Jilin City Central Hospital, Jilin 132011, China)

机构地区：[1]吉林市中心医院肿瘤科,132011

出　　处：《中国现代药物应用》2017年第3期107-109,共3页Chinese Journal of Modern Drug Application

摘　　要：目的分析研究新辅助化疗对胃癌手术并发症的影响。方法 40例进展期胃癌患者,将其按照编号随机分为对照组及观察组,各20例。对照组采取单纯外科手术治疗;观察组先进行新辅助化疗,新辅助化疗完成28 d后再进行外科手术治疗。比较两组患者的手术时间、出血量以及并发症的发生率。结果观察组患者的手术时间为(234.5±48.2)min、出血量为(306±24)ml,对照组患者的手术时间为(211.5±47.6)min、出血量为(214±22)ml,观察组患者的手术时间长于对照组,出血量多于对照组,差异均具有统计学意义(P<0.05)。观察组并发症发生率为40.0%,对照组并发症发生率为45.0%,比较差异无统计学意义(P>0.05)。结论新辅助化疗方案能够使得进展期胃癌患者手术以后并发症的发生率得到有效控制,不会增加临床手术的风险,具有临床推广价值。Objective To analyze and study the effect of neoadjuvant chemotherapy for complications of gastric cancer surgery. Methods A total of 40 advanced gastric cancer patients were divided by serial number into control group and observation group, with 20 cases in each group. The control group received simple surgery for treatment, and the observation group received neoadjuvant chemotherapy first and then surgery in 28 dafter neoadjuvant chemotherapy. Comparison were made on operation time, bleeding volume, and incidence of complications in two groups. Results The observation group had operation time as (234.5±48.2) min, bleedingvolume as (306±24) ml, and the control group had operation time as (211.5±47.6) min and bleeding volume as(214±22) ml. The observation group had longer operation time than the control group, and more bleeding volume than the control group. Their differences had statistical significance (P<0.05). The observation group had incidenceof complications as 40.0%, and the control group had incidence of complications as 45.0%, and there was nostatistically significant difference in two groups (P>0.05). Conclusion Neoadjuvant chemotherapy regimen caneffectively control the incidence of complications in advanced gastric cancer patients, without increasing risk of clinical surgery. This method has clinical promotion value.

关 键 词：新辅助化疗 胃癌手术 并发症 

分 类 号：R735.2[医药卫生—肿瘤]