小剂量奥曲肽联合前列地尔在肝硬化腹水中的疗效观察  

Curative effect observation of low-dose octreotide combined with alprostadil in cirrhotic ascites

作　　者：张春子[1] 黄震国[1] ZHANG Chun-zi;HUANG Zhen-guo(Department of Digestion, Yanji City Hospital, Yanji 133000, China)

机构地区：[1]延吉市医院消化科,133000

出　　处：《中国现代药物应用》2017年第5期68-70,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨小剂量奥曲肽联合前列地尔治疗肝硬化腹水的临床疗效。方法 58例单纯肝硬化腹水或合并少量胸水患者,随机分为观察组和对照组,每组29例。两组常规限制钠、水摄入及补充白蛋白,给予速尿静脉滴注和保肝治疗,在此基础上对照组使用前列地尔治疗,观察组给予小剂量奥曲肽联合前列地尔治疗。治疗2周后比较两组患者的疗效、腹围、24 h尿量、体重变化、门静脉主干内径等指标。结果治疗前两组患者腹围、尿量、体重、门静脉主干内径指标比较差异无统计学意义(P>0.05)。治疗后,观察组各项观察指标明显优于对照组,差异有统计学意义(P<0.05)。观察组治疗总有效率为89.7%,高于对照组的62.1%,差异有统计学意义(P<0.05)。结论采用前列地尔与小剂量奥曲肽联合的方式对肝硬化腹水患者进行治疗,可有效减少腹水及胸水量,降低门静脉压力,有助于患者迅速恢复。Objective To explore the clinical effect of low-dose octreotide combined with alprostadil in cirrhotic ascites. Methods A total of 58 cirrhotic ascites only or complicated with small amount ofhydrothorax patients were randomly divided into observation group and control group, with 29 cases in each group. Both groups received conventional limit sodium, water intake and albumin supplementation, and intravenous drip of furosemidum and liver protection treatment. The control group received alprostadil for treatment, and the observation group received low-dose octreotide combined with alprostadil for treatment. Comparison were made on curative effect abdominal girth, 24 h urine volume, weight changes and main portal vein diameter after 2 weeks of treatment in two groups. Results There were no statistically significant difference in abdominal girth,24 h urine volume, weight changes and main portal vein diameter before treatment (P>0.05). After treatment,the observation group had better observation indicators than the control group, and the difference had statistical significance (P<0.05). The observation group had higher total treatment effective rate as 89.7% than 62.1% in the control group, and the difference had statistical significance (P<0.05). Conclusion For the treatment of cirrhotic ascites patients, combination of low-dose octreotide and alprostadil can effectively reduce ascites and hydrothorax volume, decrease portal vein pressure, and help patients to recover quickly.

关 键 词：肝硬化腹水 奥曲肽 前列地尔 疗效 

分 类 号：R575.2[医药卫生—消化系统]