纳米炭在胃癌个体化淋巴结清扫术中的应用  

Application of nano-carbon particle as trace agent for dissection of metastatic lymph nodes in gastric cancer patients

作　　者：陈柏庆[1] 章健[1] 张黎[2] 梁军[1] 张涛[1] 裴俊烽[1] 张前进[1] 金冬春 傅江河 茅育蕾[2] CHEN Baiqing;ZHANG Jian;ZHANG Li(Department of Surgical Oncology,Affiliated Hospital of Shaoxing University,Shaoxing 312000,China)

机构地区：[1]绍兴文理学院附属医院肿瘤外科,312000 [2]绍兴文理学院附属医院病理科,312000

出　　处：《浙江医学》2017年第6期435-437,共3页Zhejiang Medical Journal

基　　金：浙江省教育厅科研计划项目(Y201226061);绍兴市科技局科研计划项目(2013D10043);浙江省医学会临床科研项目(2013ZYC-B);浙江省医药卫生技术成果项目(2017ZH024)

摘　　要：目的探讨胃癌根治术中应用纳米炭作为示踪剂指导个体化淋巴结清扫的可行性和临床效果。方法回顾性分析术中注射纳米炭行胃癌D2(部分D2+)根治术的111例患者围术期资料(研究组),取同期未应用纳米炭示踪行常规胃癌D2(部分D2+)根治术的106例患者作为对照组,比较两组患者手术时间、术中出血量、住院时间、清扫淋巴结个数并详细分组(N1、N2、部分N3淋巴结)、转移淋巴结个数。结果两组患者手术时间、术中出血量、住院时间比较均无统计学差异(均P<0.05)。两组患者术中清扫的淋巴结情况比较,除外N1淋巴结,研究组患者清扫、转移淋巴结,N2、部分N3淋巴结,微小N1、N2、部分N3淋巴结个数均大于对照组(均P<0.05)。结论在胃癌根治术中应用纳米炭示踪剂简单、可行,可指导个体化淋巴结的清扫范围,增加转移淋巴结检出率,利于临床作出准确的肿瘤分期,指导术后化疗方案的制定。Objective To investigate the feasibility and clinical effect of the application of nano-carbon particle as a trace agent in radical gastrectomy for gastric cancer. Methods The clinical data of 111 patients with gastric cancer undergoing D2(D2+) radical gastrectomy with intraoperative injection of nano-carbon particles (study group) and 106 patients undergoing D2(D2+) radical resection without injection of nano-carbon particles (control group) were retrospectively analyzed. The operation time, intraoperative blood loss, hospitalization time, dissected lymph node number(N1, N2, partial N3 lymph node) and metastatic lymph node number were compared between two groups. Results There was no significant difference in operation time, blood loss and hospitalization time between the two groups (P<0.05). The number of dissected and metastatic lymph nodes in study group was significantly higher than that of control group, except N1 lymph nodes (P<0.05). Conclusion The intraoperative application of nano-carbon particle is simple and feasible for guiding the dissection of individual lymph nodes, which can increase the detection rate of lymph node metastasis, and is beneficial to accurate clinical staging and postoperative chemotherapy.

关 键 词：纳米炭 胃肿瘤 淋巴示踪剂 手术 

分 类 号：R735.2[医药卫生—肿瘤]