类风湿关节炎和慢性牙周炎临床指标的相关性研究  

Relationship of clinical index between rheumatoid arthritis and chronic periodontitis

作　　者：辛蔚妮[1] 侯志铎[2] 龚瑶[3] XIN Wei-ni;HOU Zhi-duo;GONG Yao(Stomatology Department, The First Affiliated Hospital of Shantou University Medical College,Shantou 515000, China;Rhematology Department, The First Affiliated Hospital of Shantou University Medical College, Shantou 515000, China;Rhematological laboratory, Shantou University Medical College, Shantou 515000, China)

机构地区：[1]汕头大学医学院口腔医学系,汕头大学医学院第一附属医院口腔科,广东汕头515000 [2]汕头大学医学院第一附属医院风湿科,广东汕头515000 [3]汕头大学医学院风湿病研究室,广东汕头515000

出　　处：《口腔疾病防治》2017年第4期227-230,共4页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：广东省医学科学技术研究基金(A2014442)

摘　　要：目的研究类风湿关节炎(rheumatoid arthritis,RA)患者的牙周状况,初步探讨慢性牙周炎(chronic periodontitis,CP)与RA的关系。方法收集48例诊断为类风湿关节炎患者作为RA组,同时在口腔门诊中进行常规龈上洁治的、无特殊口腔疾病的患者中选择42例作为健康对照组。记录相关的类风湿的临床指标,包括红细胞沉降率(erythrocyte sedimentation rate,ESR)、C反应蛋白(C-reactive protein,CRP)、血清中抗环瓜氨酸化抗体(anticycliccitrullinated peptide antibody,Anti-CCP)和口腔指数,包括非刺激性唾液流速(unstimulated salivary flow rate,UWS)、刺激性唾液流速(stimulated salivary flow rate,SWS)、探诊出血指数(bleeding on probe,BOP)、牙周袋探诊深度(periodontal probing pocket,PPD)、临床附着水平(clinical attachment level,CAL),并做均数比较及相关性分析。结果 RA组与健康对照组在唾液流速、PPD、CAL等口腔指标方面差异均具有统计学意义(P<0.05)。RA组中慢性牙周炎的发病率与健康对照组的发病率存在差异(P<0.001)。CAL与AntiCCP抗体浓度具有相关性(P=0.01)。结论 RA患者慢性牙周炎发病率较健康人高,类风湿关节炎与慢性牙周炎在发病机制有可能存在一定的关联性。Objective To explore the relationship betweenrheumatoid arthritis(RA)and chronic periodontitis(CP).Methods A total of48RA patients were recruited from the Rhematology Department of The First Affiliated Hospitalof Shantou University Medical College(SUMC).RA patients were matched on age and gender with healthy controls,whowere recruited from the Stomatology Department.Dental parameters including unstimulated salivary flow rate(UWS),stimulated salivary flow rate(SWS),bleeding on probe(BOP),periodontal probing pocket(PD),clinical attachment level(CAL)and decayed,missing and filling(DMF)were recorded in all cases.Erythrocyte sedimentation rate(ESR),C?reac?tive protein(CRP)and Anticyclic citrullinated peptide antibody(AntiCCP)were also recorded in RA patients.Results There were significant difference between RA group and health control group on salivary flow rate,BOP,PD,CAL and DMF(P<0.001).Higher percentage of RA patients were diagnosed as periodontal disease than those in con trol group(P<0.001).There was relationship between CAL and Anti?CCP antibody(P<0.001).Conclusion RA pa?tients have higher risk of CP,and there might be relationship between RA and CP.

关 键 词：慢性牙周炎 类风湿关节炎 抗环瓜氨酸肽抗体 唾液流速 临床附着水平 

分 类 号：R781.4[医药卫生—口腔医学]