Apelin在神经系统中作用的研究进展  

Research progresses of apelin in nervous system

作　　者：魏珍玉[1] 吴丹红[1] WEI Zhen-yu;WU Dan-hong(Department of Neurology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201999, China)

机构地区：[1]上海交通大学医学院附属第九人民医院神经内科,上海201999

出　　处：《上海交通大学学报（医学版）》2017年第5期704-707,共4页Journal of Shanghai Jiao tong University:Medical Science

基　　金：上海市科委科研基金(14411972000);上海交通大学"医工交叉"科研基金(YG2013MS23);上海交通大学医学院科研基金(152H2013)~~

摘　　要：Apelin是孤儿G蛋白偶联受体-血管紧张素受体样蛋白J受体的内源性配体,其前蛋白是由X染色体编码的77个氨基酸组成的多肽。Apelin/apelin受体系统在体内分布广泛,参与多种生理病理机制的调节。已经证明血清apelin与多种疾病的发生和发展相关,包括心血管疾病、肺动脉高压、肾脏疾病、肿瘤和内分泌系统疾病等。目前apelin在神经系统研究亦逐渐展开。该文以apelin为主线,总结了apelin在神经系统的分布及其病理生理作用,同时阐述apelin在神经系统相关疾病发生和发展中的作用。Apelin is the endogenous ligand of a G protein-coupled receptor called APJ,its propeptide is an X-linked and coded peptide with77amino acids.Apelin/apelin receptor system is widely distributed in the body and is involved in various physiological and pathological regulations.It has been demonstrated that apelin is associated with the occurrence and development of many diseases,including angiocardiopathy,pulmonary arterial hypertension,nephropathy,cancer,endocrine disease,and so on.Currently,studies on apelin in nervous system have been developed gradually.This article focuses on apelin and summarizes the distribution and pathophysiological roles of apelin in nervous system,as well as in the occurrence and development of diseases associated with nervous system.

关 键 词：APELIN 神经系统 脑损伤 认知障碍 

分 类 号：R741[医药卫生—神经病学与精神病学]