加味二仙汤联合阿仑膦酸钠维D_3片治疗绝经后骨质疏松症的临床研究  

Clinical observation on treating osteoporosis after menopause with the Erxian decoction plus alendronate-dimensional D_3

作　　者：陈苑妮[1] 

机构地区：[1]佛山市中医院,广东佛山528000

出　　处：《中医临床研究》2017年第17期11-13,共3页Clinical Journal Of Chinese Medicine

摘　　要：目的:探讨加味二仙汤联合阿仑膦酸钠维D3片治疗绝经后骨质疏松症的临床疗效。方法:将符合纳入标准的绝经后骨质疏松症患者120例按随机数字表法分为治疗组60例和对照组60例,对照组口服阿仑膦酸钠维D3片,治疗组用加味二仙汤联合阿仑膦酸钠维D3片治疗,分别观察和比较两组患者中医症状总积分、骨密度(BMD)、血清中碱性磷酸酶(ALP)、骨钙素(BGP)、钙离子(Ca)含量变化以及临床疗效。结果:治疗前,两组患者中医症状总积分比较,差异无统计学意义(t=0.3775;P=0.7065),治疗后,治疗组中医症状总积分较对照组下降更明显,差异有统计学意义(t=8.5143;P<0.001);治疗前两组患者L1-4、Neck、Troch、Inter、Ward's部位骨密度比较,差异无统计学意义(P>0.05),治疗后两组患者各部位骨密度均较治疗前增加,且治疗组较对照组更明显,差异有统计学意义(P<0.05);治疗前两组患者血清中ALP、BGP、Ca含量比较,差异无统计学意义(P>0.05),治疗后,治疗组血清中ALP、BGP、Ca含量变化较对照组更明显,差异有统计学意义(P<0.05);治疗组总有效率(86.7%)明显优于对照组(68.3%),差异有统计学意义(P=0.0009)。结论:加味二仙汤联合阿仑膦酸钠维D3片治疗绝经后骨质疏松症临床疗效较好,值得临床推广应用。Objective:To explore clinical efficacy of the Erxian decoction plus alendronate-dimensional D3on osteporosis.Methods:120cases were divided into the treatment group and control group,60cases in each group.The control group took alendronate-dimensionalD3.The treatment group took the Erxian decoction more.Results:After treatment,the total scores of TCM symptoms in the treatment groupwere decreased more than the control group(P<0.05).After treatment,the bone mineral density in two groups was higher than beforetreatment,and that in the treatment group was more obvious than the control group(P<0.05).After treatment,the changes of serum ALP,BGP and Ca in the treatment group were more significant than those in the control group(P<0.05).The total efficaiency was86.7%in thetreatment group,better than68.3%in the control group(P=0.0009).Conclusion:The Erxian decoction plus alendronate-dimensional D3iseffective on osteoporosis,and is worthy of clinical application.

关 键 词：加味二仙汤 阿仑膦酸钠维D3 片 绝经后骨质疏松症 

分 类 号：R223.7[医药卫生—中医基础理论]