石家庄地区人群对氧磷酶3基因多态性研究  

Genetic polymorphism of paraoxonase 3 among population in Shijiazhuang regionm

作　　者：范志亮[1,2] 冯晓娟[3] 李春岩[1] 田新英[1] 任文博[1,4] FAN Zhi-liang;FENG Xiao-juan;LI Chun-yan;TIAN Xin-Ying;REN Wen-Bo(Department of Neurology, the Second Hospital of Hebei Medical University,Shijiazhuang 05000, China)

机构地区：[1]河北医科大学第二医院神经内科河北省神经病学重点实验室,石家庄050000 [2]邢台市人民医院神经内三科 [3]邢台市人民医院超声科 [4]天津市第五中心医院神经内科

出　　处：《脑与神经疾病杂志》2017年第7期438-441,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨石家庄地区人群对氧磷酶3(PON3)A99A基因多态性的分布情况。方法应用聚合酶链式反应—限制性酶切片段长度多态性(PCR-RFLP)。方法对209例石家庄地区健康汉族人进行PON3 A99A基因多态性分析。结果石家庄地区汉族人群PON3 A99A基因多态性符合Hardy-Weinberg遗传平衡定律,具有代表性。石家庄地区人群、海南地区黎族人群、美国人群和意大利人群PON3 A99A基因型分布均各不相同(P<0.05)。石家庄地区人群、北京地区人群、海南地区黎族人群、美国人群、英国人群和意大利人群PON3 A99A等位基因分布频率各不相同,差异显著(P<0.05)。结论石家庄地区人群PON3A99A基因型频率分布和等位基因频率有其独特性。PON3 A99A的基因多态性在地域和人种中的分布有差异(P<0.05)。Objective To study the paraoxonase3A99A genetic polymorphisms among healthy population of Shijiazhuang region.Method Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was used to detect the genotypes of PON3A99A in two hundred and nine healthy Han population of Shijiazhuang region.Results The genotype distribution of the Shijiazhuang region Han population was in good agreement with Hardy-Weinberg equilibrium.The results suggest that there exist polymorphisms in PON3A99A among healthy Han population of Shijiazhuang region.The genotype distribution of the PON3A99A in Shijiazhuang region population、Hainan Li nationality、American and Italians are significantly different(P<0.05).The distribution of allele frequency of the PON3A99A in Shijiazhuang region population、Beijing population、Hainan Li nationality、American、English and Italians are significantly different(P<0.05).Conclusion The PON3A99A gene polymorphism in Shijiazhuang region healthy population has its own characteristics.The PON3A99A gene polymorphisms'geographic and ethnic distribution is significantly different(P<0.05)

关 键 词：基因频率 石家庄地区 对氧磷酶3 基因 多态性 

分 类 号：R743.32[医药卫生—神经病学与精神病学]