灰度图像校正在视网膜内源光信号探测中的应用  

Application of Gray Image Level Correction in the Detection of Intrinsic Optical Signals in Retina

作　　者：张洁瑞 郭学谦[2] 马丽萍[2] 侯钧杰 邵双运[1] ZHANG Jie-rui;GUO Xue-qian;MA Li-ping;HOU Jun-jie;SHAO Shuang-yun(School of Science, Beijing JiaotongUniversity, Beijing 100044, China;;Beijing Key Laboratory of FundamentalResearch on Biomechanics in ClinicalApplication, Capital Medical University,Beijing 100069, China)

机构地区：[1]北京交通大学理学院,北京100044 [2]首都医科大学生物医学工程学院,首都医科大学临床生物力学应用研究北京市重点实验室,北京100069

出　　处：《中国医疗设备》2017年第7期51-55,共5页China Medical Devices

基　　金：北京市教育委员会科技计划一般项目(KM201610025010)

摘　　要：目的对视网膜内源光信号的图像进行预处理,消除测试眼因眨眼抖动而产生的图像位置偏移;降低因图像灰度不均匀而产生的背景噪声。方法本文首先采用归一化相关系数匹配法对图像进行配准,然后采用灰度线性变换对获取的图像进行灰度校正,最后提取视网膜黄斑区的内源光信号。结果灰度图像校正能有效提高内源光信号的相对强度,波谷幅度相对处理之前增强两倍(5%提高到12%;12%提高到26%);还可以改善内源光信号变化曲线,能观察到更多的信号细节变化。结论文中方法与已有文献中的结果相似,说明该方法是有效可靠的,为探索信号生理学意义奠定了基础。Objective The image of intrinsic optical signals(IOSs)was preprocessed to eliminatethe image position offset caused by the blink of the test eye and to reduce background noise causedby image gray level uneven.Methods We have adopted the normalized correlation coefficientof registration for image registration.Then,the gray linear transformation was used to obtainimage gray scale correction.Finally we extracted IOSs of the macular area in retinal.ResultsExperimental results indicated that it could effectively improve the relative intensity of IOSs,troughamplitude was twice as high as the relative treatment(5%to12%;12%to26%);in addition,wecould observe more changes in signal details by improve the endogenous optical signal curve.Conclusion The results we get are similar to the results of existing literature.Thus,the methodis effective and reliable,which lay a foundation for exploring signal physiology significance.

关 键 词：光学成像 灰度处理 内源光信号 信号探测 视网膜 

分 类 号：R770.4[医药卫生—眼科] TN911.6[医药卫生—临床医学]