趋化因子受体4和基质衍生因子1的表达与卵巢癌发生的相关性分析  

Correlation analysis between expression of chemokine receptor 4 and matrix derived factor 1 and ovarian cancer

作　　者：郭玲[1] 李莲娣[2] 尹国华[3] 崔虎军[4] GUO Ling;LI Liandi;YIN Guohua;CUI Hujun(Personnel Section, the Second Affiliated Hospital of Mudanjiang Medical University, Heilongjiang, Mudanjiang 157000, China;Department of Anesthesiology, The Second Affiliated Hospital of Mudanjiang Medical University,Heilongjiang, Mudanjiang 157000, China;Department of Nursing, the Second Affiliated Hospital of Mudanjiang Medical University, Heilongjiang, Mudanjiang 157000, China;Department of Oncology, Affiliated Hongqi Hospital of Mudanjiang Medical College, Heilongjiang, Mudanjiang 157000, China)

机构地区：[1]牡丹江医学院第二附属医院人事科,黑龙江牡丹江157000 [2]牡丹江医学院第二附属医院麻醉科,黑龙江牡丹江157000 [3]牡丹江医学院第二附属医院护理部,黑龙江牡丹江157000 [4]牡丹江医学院附属红旗医院肿瘤科,黑龙江牡丹江157000

出　　处：《中国医药科学》2017年第11期22-24,103,共4页China Medicine And Pharmacy

基　　金：黑龙江省牡丹江市科学技术计划项目(Z2016s0095)

摘　　要：目的分析趋化因子受体4(CXCR4)和基质衍生因子1(SDF-1)在不同卵巢组织中的表达,探究二者在卵巢癌的发生、发展及转移过程中的作用。方法选择我院收治的35例卵巢上皮癌患者、卵巢上皮性良性肿瘤的患者27例以及正常的卵巢组织患者32例,采用免疫组化法进行检测,分析卵巢组织中的CXCR4、SDF-1的蛋白表达情况和临床病理因素的相关性。结果 SDF-1、CXCR4在正常卵巢组织、卵巢良性肿瘤肿瘤和卵巢恶性肿瘤中分别表达阴性、低表达以及高表达(P<0.05);SDF-1、CXCR4蛋白表达与FIGO分期、组织学分化均无显著差别(P>0.05),而和淋巴结是否转移呈正相关(P<0.05),SDF-1表达情况与患者具有腹水呈正相关(P<0.05)。结论 SDF-1、CXCR4的蛋白表达和卵巢癌有着一定的相关性,其可能参与了卵巢癌的转移过程,但是与卵巢癌的组织学分化情况无关,同时SDF-1、CXCR4的蛋白表达情况可以作为卵巢的重要致病因子。Objective To analyze the expression of chemokine receptor4and matrix derived factor1in different ovarian tissues.And to explore the the role of the two in the process of ovarian cancer occurrence,development and metastasis.Methods32patients with epithelial ovarian cancer,27cases of ovarian epithelial benign tumors and35cases of normal ovarian tissues cured in our hospital were selected.Immunohistochemical method was used to detect the expression of CXCR4and SDF-1proteins in ovarian tissue and the correlation between clinical and pathological factors.Results SDF-1and CXCR4expressed negative,low expression and high expression(P<0.05)in normal ovarian tissue,ovarian benign tumor and ovarian malignant tumor respectively.There was no significant difference between the expression of SDF-1and CXCR4protein and FIGO staging and histological differentiation(P>0.05).There was positively related to lymph node metastasis(P<0.05),and the expression of SDF-1was positively correlated with ascites in patients(P<0.05).Conclusion The protein expression of SDF-1and CXCR4is related to ovarian cancer.It may be involved in the metastasis of ovarian cancer,but it is not related to the histological differentiation of ovarian cancer.At the same time,the expression of SDF-1and CXCR4protein can be an important pathogenic factor of ovary.

关 键 词：趋化因子受体4 基质衍生因子1 卵巢癌 淋巴结 相关性 

分 类 号：R737.31[医药卫生—肿瘤]