CD73分子在肿瘤中的重要作用  

Role of CD73 in cancer

作　　者：高姚怡(综述) 马晓路(综述)[1] 吴炯(综述)[1] 郭玮(校审)[1] 潘柏申(校审)[1] GAO Yaoyi;MA Xiaolu;WU Jiong;GUO Wei;PAN Baishen(Department of Clinical Laboratory,Zhongshan Hospital,Fudan University,Shanghai 200032,China)

机构地区：[1]复旦大学附属中山医院检验科,上海200032

出　　处：《检验医学》2017年第7期656-662,共7页Laboratory Medicine

基　　金：国家自然科学基金面上项目(81572064);上海市卫生计生系统重要薄弱学科建设项目(2015ZB0201)

摘　　要：嘌呤在肿瘤的发展过程中扮演着重要的角色,该信号通路受到一系列核苷酸酶调控。在这些酶中,CD73是关键酶之一,可以催化磷酸腺苷(AMP)水解为腺苷,从而介导腺苷的生物学作用。目前的研究已经发现CD73高表达于多种实体肿瘤,多个因子和机制都参与CD73表达的调控。越来越多的研究发现,CD73是体外肿瘤细胞增殖、转移和侵袭,体内肿瘤血管生成和肿瘤免疫逃逸机制的关键调控分子。体内试验的证据显示,对于肿瘤患者,靶向阻断CD73将成为有效的治疗手段。文章总结了CD73在肿瘤发展过程中的重要作用,包括其对于肿瘤血管生成的促进作用、影响肿瘤生长和转移的机制、对肿瘤微环境中免疫系统的抑制效应以及未来抗CD73分子的治疗与展望。Purine plays an important role in cancer progression,and is regulated by a series of nucleotidases.CD73is one of key enzymes.CD73can catalyze adenosine monophosphate(AMP)breakdown to adenosine,and is found to be overexpressed in many types of cancers.There are various factors and mechanisms for regulating the expression of CD73.More and more studies have shown that CD73is a key regulatory molecule of in vitro cancer cell proliferation,migration and invasion and in vivo tumor angiogenesis and tumor immune escape.Evidences in in vivo model prove that targeted blockade of CD73could be a favorable therapeutic approach for cancer patients.This review will summarize the roles of CD73in cancer development,including tumor angiogenesis,tumor growth and metastasis,suppressing the efficiency of immune response and the status of anti-CD73cancer therapy.

关 键 词：CD73 腺苷 靶向治疗 肿瘤 

分 类 号：R446.62[医药卫生—诊断学]