胶质瘤LDHA和突变型p53蛋白联合表达的临床病理学意义  

The clinicopathological significances of LDHA and mutant p53 co-expression in gliomas

作　　者：赖妙玲[1,2] 郝卓芳[2] 黄世章[2] 欧阳小明[2] 郅程[2] 申洪[1] LAI Miaoling;HAO Zhuofang;HUANG Shizhang;OUYANG Xiaoming;ZHI Cheng;SHEN Hong(Department of Pathology,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学南方医院病理科,广州市510515 [2]广州医科大学附属第二医院病理科,广州市510260

出　　处：《实用医学杂志》2017年第14期2275-2280,共6页The Journal of Practical Medicine

基　　金：广东省科技计划资助项目(编号:2010B060300001)

摘　　要：目的探讨LDHA/p53联合表达在胶质瘤临床病理学中的意义。方法按照2016年WHO中枢神经系统肿瘤新分类,分析68例胶质瘤LDHA和突变型p53蛋白的表达特点及其与临床病理特征的关系。结果 68例胶质瘤中,LDHA单独高表达多为高级别胶质瘤,占48.5%;突变型p53高表达则多为胶质母细胞瘤,占26.5%。LDHA/p53联合表达在胶质母细胞瘤中显著增高,占22.1%(P=0.005)。高级别胶质瘤中LDHA/p53联合表达增多,占27.9%(P=0.002)。结论 LDHA/p53联合表达有助于高级别胶质瘤的诊断,对胶质母细胞瘤的诊断也具有提示作用。Objective To investigate the clinicopathological significances of LDHA/mutant p53co?expression in gliomas.Methods According to the2016WHO CNS,archived68gliomas were collected and analyzed retrospectively.The co?expression of LDHA/mutant p53was detected by immunohistochemical staining.Results High expression of LDHA alone was always found in high grade gliomas(48.5%).Mutant p53high expression was usually observed in glioblastomas(26.5%).There was a close relationship between co?expression of LDHA/mutant p53in glioblastoma(27.9%,P=0.005),or gliomas with high histological grading(27.9%,P=0.002).Conclusions Co?expression of LDHA/mutant p53in tumor cells might be a specific immunohistochemical phenotype of gliomas,and may help for distinguishing glioblastoma and other high grade gliomas from low grade gliomas.

关 键 词：胶质瘤 乳酸脱氢酶-A亚基(LDHA) 突变型P53 异柠檬酸脱氢酶1(IDH1) 鉴别诊断 

分 类 号：R739.41[医药卫生—肿瘤]