肿瘤来源于受损干细胞的过度修复假说的提出及意义  

Tumors Arise from Excessive Repair of Damaged Stem Cells: a New Hypothesis and Its Significance

作　　者：陈照立[1] 杨栋[1] 杨丹凤[1] 苗静[1] 刘伟丽[1] 王新兴[1] 邱志刚[1] 金敏[1] 谌志强[1] 李君文[1] CHEN Zhaoli;YANG Dong;YANG Danfeng;MIAO Jing;UU Weili;WANG Xinxing;QIU Zhigang;JIN Min;SHEN Zhiqiang;II Junwen(Tianjin Institute of Health and Environmental Medicine,Tianjin 300050, China)

机构地区：[1]军事医学科学院卫生学环境医学研究所,天津300050

出　　处：《解放军预防医学杂志》2017年第5期533-536,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：尽管已经提出多个肿瘤发生的假说,但截至目前,均不能对肿瘤的发生和发展进行全面、合理的解释。本文提出"肿瘤来源于受损干细胞的过度修复"的新假说,以期为阐释肿瘤的发生发展机制提供新的依据,并对新假说在解释肿瘤的发生机制,以及在指导肿瘤的早期诊断和有效预防等方面的意义进行了阐述。Despite the large number of hypotheses about tumorigenesis,few of them can account for the occurrence and development of tumors in depth.A new hypothesis that tumors arise from the excessive repair of damaged stem cells is raised in this review.Hopefully it might provide evidence for explaining mechanisms of occurrence and development of tumors,solving the puzzles between occurrence,development,metastasis and recovery of tumors,and guiding early diagnosis and effective prevention of tumors.

关 键 词：肿瘤 干细胞损伤 过度修复 假说 

分 类 号：R730.2[医药卫生—肿瘤]