WT-1在中枢神经系统孤立性纤维性肿瘤/血管周细胞瘤中表达及临床病理学研究  

Clinicopathological analysis of WT-1 expression in solitary fibrous tumor/haemangiopericytoma of central nervous system

作　　者：吴海波[1] 李恒[1] 钟文[1] WU Haibo;LI Heng;ZHONG Wen(Department of Pathology ^Anhui Provincial Hospital y Hefei yAnhui 230001, China)

机构地区：[1]安徽省立医院南区病理科

出　　处：《安徽医药》2017年第8期1402-1405,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨WT-1在中枢神经系统孤立性纤维性肿瘤/血管周细胞瘤(SFT/HPC)中的表达情况及临床病理学意义。方法回顾性分析36例中枢神经系统SFT/HPC的WT-1免疫组织化学染色情况,以29例脑膜瘤作为对照。结果 SFT/HPC以瘤细胞围绕血管形成血管外皮瘤样结构为特点,肿瘤小血管呈WT-1强弱不等的阳性表达或不表达,而毛细血管呈弥漫性强阳性表达。在脑膜瘤中,WT-1表达与肿瘤血管的大小和肿瘤的类型及分级无明显关联性(r=0.027 27,P=0.757 2)。结论WT-1可作为SFT/HPC区别脑膜瘤的标记物,将来也可作为抗SFT/HPC血管生成治疗的潜在靶点。Objective To investigate the expression of WT-1in solitary fibrous tumor/haemangiopericytoma(SFT/HPC)of central nervous system and its clinicopathological significance.M ethods Retrospective analysis was conducted of the immunohistochemical staining of WT-1in36cases of SFT/HPC of central nervous system,29cases of meningioma were used as control.Results SFT/HPC was characterized by the formation of haemangiopericytoma-like structure.The small vessels of the tumors exhibited positive expression or no expression of WT-1,while the capillaries diffusely and strongly expressed WT-1protein.The expression of WT-1was not correlated with the size of tumor vessels,the types and the grades of meningioma(r=0.02727,P=0.7572).Conclusion WT-1can be used as a marker to differentiate meningiomas from SFT/HPC,and may also be a potential target for anti-angiogenic treatment in SFT/HPC.

关 键 词：WT-1 中枢神经系统 孤立性纤维性肿瘤 血管周细胞瘤 

分 类 号：R739.4[医药卫生—肿瘤]