Schwann细胞在髓鞘形成过程中的极性调控  

Regulation of the polarization of Schwann cell during myelination

作　　者：万丽丹[1,2] 刘厚奇[3] 丁文龙[2] Wan Lidan;Liu Houqi;Ding Wenlong(Department of Anatomy , Basic medical school , Nanchang University, Nanchang 330006;Department of Histology and Embryology, The Second Military Medical University , Shanghai 200433;Department of Anatomy , School of Medicine , Shanghai Jiaotong University , Shanghai 200025, China)

机构地区：[1]南昌大学基础医学院人体解剖学教研室,南昌330006 [2]上海交通大学基础医学院解剖学教研室,上海200025 [3]第二军医大学组织胚胎学教研室,上海200433

出　　处：《中国组织化学与细胞化学杂志》2017年第4期383-388,共6页Chinese Journal of Histochemistry and Cytochemistry

基　　金：江西省自然科学基金(00014918);南昌大学博士科研启动基金

摘　　要：周围神经系统髓鞘形成依赖Schwann细胞和神经元之间复杂的相互作用。细胞极性分子蛋白Par-3在Schwann细胞与轴突接触面密集分布,为BDNF/p75NTR介导的启动成髓提供分子支架。然而,Par-3在该界面聚集并呈不对称性分布的机制仍是一个谜。不少研究发现,JAM和nectin等细胞粘附分子与Par-3不对称性分布有关。另外,通过改变轴突信号如神经营养因子和神经素的水平,也能影响Schwann髓鞘的形成。本文综述和阐释在髓鞘形成过程中,Schwann细胞极性是如何被调控的。The cellular events that preceding myelination in the peripheral nervous system is dependent on complex reciprocalinteractions between Schwann cell(SC)and axon.The Par-3,as an intracellular scaffold,is enriched at SC-axon interface and functionsfor BDNF/p75NTR to promote myelination initiation.However,the mechanism of Par-3recruitment and asymmetrical distribution at thispolarized-apical domain remains a mystery.Many studies have found that junctional adhesion molecule(JAM)and Nectin and othercell adhesion molecules were related to the asymmetric distribution of Par-3at SC-axon interface.In addition,changes in axonal signaling,such as neurotrophic factor or neuregulin-1,can also contribute to the formation of Schwann myelin.The purpose of this paperis to summarize and explain how the polarity of Schwann cells is regulated during myelination.

关 键 词：SCHWANN细胞 髓鞘形成 细胞极性 Par-3 

分 类 号：R338.11[医药卫生—人体生理学]