血清甲状腺激素对脑卒中事件的影响  

Influence of serum thyroid hormone on acute stroke event

作　　者：刘帮慧[1] 张瑛[1] Bang-hui Liu;Ying Zhang(Department of Neurology, Jingzhou Central Hospital, Jingzhou, Hubei 434020, China)

机构地区：[1]湖北省荆州市中心医院神经内科,湖北荆州434020

出　　处：《中国现代医学杂志》2017年第18期98-101,共4页China Journal of Modern Medicine

摘　　要：目的通过分析急性脑卒中患者甲状腺激素水平的变化,探讨甲状腺激素与脑卒中事件的关系。方法选取2015年6月-2016年6月发病7 d内的急诊脑卒中患者164例为急性脑卒中组,健康查体者180例为健康对照组。检测血三碘甲状腺原氨酸(T_3)、甲状腺素(T_4)、FT_3(游离T_3)、FT_4(游离T_4)、促甲状腺素(TSH)、血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)、血糖、纤维蛋白原(FIB)及同型半胱氨酸的浓度。比较两组甲状腺激素水平的变化,分析甲状腺激素与脑卒中事件的关系。结果 (1)急性脑卒中组FT4较健康对照组比较降低[(15.41±2.83)vs(16.78±3.74),P=0.027],FT_3、T_3、T_4及TSH与健康对照组比较差异无统计学意义(P>0.05)。(2)急性脑卒中组FIB、血糖、TC、LDL、载脂蛋白B及同型半胱氨酸(Hcy)较健康对照组升高(P<0.05);HDL、载脂蛋白A及三酰甘油在两组比较差异无统计学意义(P>0.05)。(3)Logistics回归分析提示FT4增高使脑卒中风险减低81.9%(1/OR),高血糖和高Hcy分别使脑卒中风险增加2.94和1.07倍(1/OR)。结论血清FT4减低可增加脑卒中事件发生的风险。Objective To study the relationship between thyroid hormone and acute stroke event by analysis of the variety of thyroid hormone in acute stoke patients.Methods A total of164acute stroke patients who were first-ever stroke and within7days after symptom onset from June2015to June2016were selected as observation group,and180healthy cases were selected as control group.General conditions and previous history were collected.T3,T4,FT3,FT4,TSH,TC,TG,LDL,HDL,blood sugar,FIB and homocysteine(Hcy)in the blood were tested.Results FT4was lower in the observation group than in the control group[(15.41±2.83)vs(16.78±3.74),P<0.05];FT3,T3,T4and TSH had no differences between the two groups(P>0.05).Compared with the heathy control group,the FIB,blood glucose,TC,LDL,ApoB and Hcy were higher in the acute stroke group(P<0.05),and there was no statistically significant difference in HDL,ApoA or TG between the two groups(P>0.05).Logistic regression analysis showed that the increase of FT4reduced the risk of stroke by81.9%(1/OR),high blood glucose and high Hcy increased the risk of stroke by2.94and1.07times(1/OR)respectivly.Conclusions The study showed that lower FT4in the blood may increase the risk of stroke.

关 键 词：急性脑卒中 甲状腺激素 游离甲状腺素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]