血小板参数和骨髓巨核细胞计数、分类在May-Hegglin异常疾病中的应用研究  

Platelet parameters and bone marrow megakaryocyte count and classification in May-Hegglin anomaly

作　　者：高峰[1] 张宏杰[1] 刘瑞芳[1] 李丽[1] 杨磊[1] 刘立国[1] 闫国艳[1] GAO Feng;ZHANG Hongjie;LIU Ruifang;LI Li;YANG Lei;LIU Liguo;YAN Guoyan(Zunhua People's Hospital,Zunhua 064200,Hebei,China)

机构地区：[1]遵化市人民医院,河北遵化064200

出　　处：《检验医学》2017年第8期668-670,共3页Laboratory Medicine

基　　金：唐山市科学技术研究与发展计划(15130240a)

摘　　要：目的评估血小板(PLT)相关参数和骨髓巨核细胞计数、分类在May-Hegglin异常(MHA)和原发性免疫性血小板减少症(ITP)中的应用价值。方法选取急性、慢性ITP患者88例,MHA疾病患者15例。同时选取正常对照者40名。分4个组进行巨核细胞计数、分类及PLT 4项参数[PLT计数、血小板压积(PCT)、血小板平均体积(MPV)、血小板体积分布宽度(PDW)]检测,并作比较。结果 MHA组PDW和MPV较急性ITP组、慢性ITP组、正常对照组显著增高(P<0.05);MHA组巨核细胞计数及分类与急、慢性ITP组比较差异有统计学意义(P<0.05),与正常对照组比较差异无统计学意义(P>0.05)。结论 MPV、PDW在MHA疾病诊断中具有较大价值;骨髓巨核细胞计数和分类可有效鉴别MHA与急、慢性ITP。Objective To evaluate the roles of platelet(PLT)parameters and bone marrow megakaryocyte count and classification in May-Hegglin anomaly(MHA)and primary immune thrombocytopenia(ITP).Methods A total of88patients with acute and chronic primary ITP were enrolled,there were15patients with MHA,and40healthy subjects were enrolled as control group.They were classified into4groups,and megakaryocyte count and classification and4parameters of PLT[PLT count,plateletcrit(PCT),mean platelet volume(MPV)and platelet volume distribution width(PDW)]were determined.Results PDW and MPV were higher in MHA group than those in acute and chronic primary ITP group and control group(P<0.05).There was statistical significance for megakaryocyte count and classification in MHA group compared with those in acute and chronic primary ITP group(P<0.05),and there was no statistical significance compared with control group(P>0.05).Conclusions MPV and PDW play roles in the diagnosis of MHA.Megakaryocyte count and classification can identify MHA and acute and chronic primary ITP.

关 键 词：MAY-HEGGLIN异常 巨核细胞 原发性免疫性血小板减少症 血小板参数 

分 类 号：R446.1[医药卫生—诊断学]