3,4,3″-三羟基对三联苯纳米混悬液制备工艺的筛选  

Screening the Preparation Process of3,4,3″-trihydroxy p-terphenyl Nanosuspension

作　　者：田晓娜 王荣梅[1] TIAN Xiao-na;WANG Rong-mei(Department of Pharmacy, The Second Hospital of Shandong University, Ji nan 250000, China)

机构地区：[1]山东大学第二医院药学部,山东济南250000

出　　处：《中国生化药物杂志》2017年第9期31-33,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的筛选3,4,3″-三羟基对三联苯纳米混悬液的制备工艺。方法采用纳米沉淀-微射流结合法制备纳米混悬液，以粒径为考察指标，通过单因素试验考察纳米沉淀过程搅拌速度及沉淀温度，微射流均质压力及循环次数对纳米混悬液粒径的影响，通过析因设计考察稳定剂的种类和用量对粒径的影响，从而筛选最佳制备工艺。结果纳米混悬液的最佳制备工艺为沉淀温度0℃，搅拌速度900rpm，微射流均质压力1600bar，循环次数12次，处方组成比例为药物：泊洛沙姆188:卵磷脂为1:0.8:0.8。结论通过优化制备工艺，成功制得粒径较低的纳米混悬液，为进一步研究奠定了基础。Objective To screen the preparation process of3,4,3″-trihydroxy p-terphenyl nanosuspension.Methods The nanosuspension wasprepared in combination with the nanoprecipitation and microfluidization method.Taken the particle size for indicator,we investigated the stirringspeed and precipitation temperature in the nanoprecipitation process,the homogeneous stress and cycles in the microfluidic process through singlefactor experiment.In addition,by factorial design,the variety and dosage of stabilizers are investigated.Results The excellent preparation conditionof the nanosuspension are as follows:0℃for the precipitation temperature,900rpm for the stirring speed,1600bar for the microfluidizationpressure and12times for cycles.The ingredient ratio for drug:poloxamer188:lecithin is1:0.8:0.8.Conclusion Through optimizing thepreparation technology,we have successfully prepared nanosuspension with lower size,which will lay a foundation for further study.

关 键 词：纳米混悬液 粒径 单因素考察 析因设计 

分 类 号：R914[医药卫生—药物化学]