Erythrocytosis caused by giant chromophobe renal cell carcinoma:a case report indicating a 9.year misdiagnosis of polycythemia vera  

作　　者：Renbo Guo Yiran Liang Lei Yan Zhonghua Xu Juchao Ren 

机构地区：[1]Department of Urology,Shandong Cancer Hospital Affiliated to Shandong University,Jinan 250117,Shandong,P.R.China [2]Department of Breast Surgery QiLu Hospital,Shandong University,Jinan 250012,Shandong,P.R.China [3]Department of Urology,QiLu Hospital,Shandong University,Jinan 250012,Shandong,P.R.China

出　　处：《Chinese Journal of Cancer》2017年第9期438-443,共6页

基　　金：financially supported by National Natural Science Foundation of China(Nos.81372335,81402108);the China Postdoctoral Science Foundation(No.2014M551915)

摘　　要：Background:Erythrocytosis,a rare paraneoplastic syndrome,generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma.Case presentation:We report a case of a young man suffering from a giant(22-cm) mass on his left kidney.Because of a history of polycythemia vera,the patient had been treated for the condition for 9 years.Radical nephrectomy was successfully performed,and the postoperative pathologic examination confirmed a diagnosis of chromophobe renal cell carcinoma.Unexpectedly,the symptom of erythrocytosis disappeared after the surgery.Further examination and analysis were performed,and we finally attributed his erythrocytosis to chromophobe renal cell carcinoma.Conclusions:Chromophobe renal cell carcinoma could cause erythrocytosis,but the clear-cut mechanism needs further research.Secondary erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera.Background: Erythrocytosis, a rare paraneoplastic syndrome, generally occurs in patients with clear cell renal cell carcinoma and has never been reported in patients with chromophobe renal cell carcinoma. Case presentation: We report a case of a young man suffering from a giant (22-cm) mass on his left kidney. Because of a history of polycythemia vera, the patient had been treated for the condition for 9 years. Radical nephrectomy was successfully performed, and the postoperative pathologic examination confirmed a diagnosis of chromophobe renal cell carcinoma. Unexpectedly, the symptom of erythrocytosis disappeared after the surgery. Further examination and analysis were performed, and we finally attributed his erythrocytosis to chromophobe renal cell carcinoma. Conclusions: Chromophobe renal cell carcinoma could cause erythrocytosis, but the clear-cut mechanism needs further research. Secondary erythrocytosis such as those related with renal tumors should be taken into consideration during the diagnosis of polycythemia vera.

关 键 词：CHROMOPHOBE RENAL cell carcinoma POLYCYTHEMIA VERA ERYTHROCYTOSIS MISDIAGNOSIS 

分 类 号：R730.5[医药卫生—肿瘤]