儿童维生素A缺乏与血红蛋白水平及呼吸道感染相关性研究  

Correlation of vitamin A deficiency with hemoglobin level and respiratory tract infection in children

作　　者：金春华[1,2] 王晓燕 张丽丽[1] 张悦[1] 李娜[1] 王建红[1] 高海涛[1] 宋文红[1] 金娜[1] 高宝峻[1] 蒋华英 王红 穆立娟 孙丽芳 任霞 付迎新 郑春梅 倪君君 张英 JIN Chunhua;WANG Xiaoyan;ZHANG Lili;ZHANG Yue;LI Na;WANG Jianhong;GAO Haitao;SONG Wenhong;JIN Na;GAO Baojun;JIANG Huaying;WANG Hong;MU Lijuan;SUN Lifang;REN Xia;FU Yingxin;ZHENG Chunmei;NI Junjun;ZHANG Ying(Department of Children Health Care, Capital Institute of Pediatrics, Beijing 100020, China;Department of Comprehensive Treatment Center, Beijing Shou Er Li Qiao Children's Hospital, Beijing 101314, China;The Civil Aviation General Hospital, Beijing 100123, China;Beijing Fangshan District Maternal and Child Health Hospital, Beijing 102400,China;Beijing Pinggu District Maternal and Child Health Care Hospital, Beijing 101200, China;Beijing Shijingshan District Maternal and Child Health Care Hospital, Beijing 100040, China;Beijing Huairou Hospital, Beijing 101400,China;Central Laboratory Beijing Harmony Health Medical Diagnostics Co, Ltd., Beijing 101111, China;Department of Paediatrics,Tsinghua University Yuquan Hospital, Beijing 100040, China)

机构地区：[1]首都儿科研究所儿童保健科,北京100020 [2]北京李桥儿童医院综合科,北京101314 [3]民航总医院儿科,北京100123 [4]北京房山区妇幼保健院儿童保健科,北京102400 [5]北京平谷区妇幼保健院儿科,北京101200 [6]北京石景山区妇幼保健院儿童保健科,北京101400 [7]北京怀柔医院儿科,北京101111 [8]北京和合医学诊断技术股份有限公司中心实验室,北京101111 [9]清华大学玉泉医院儿科,北京100040

出　　处：《临床儿科杂志》2017年第10期755-758,共4页Journal of Clinical Pediatrics

基　　金：国家卫生计生委科技发展中心临床科研专项课题(No.W2015EAE001)

摘　　要：目的了解健康儿童和伴有呼吸道感染症状儿童维生素A营养状况,及其与血红蛋白水平的相关性。方法纳入2014年12月至2015年8月期间在北京居住半年以上的健康体检儿童,检测血清视黄醇、外周血血红蛋白水平,分析维生素A营养状况与年龄、呼吸道感染及贫血的关系。结果共纳入1 742例儿童,男1 056例、女686例,中位年龄3.1岁(6个月~17岁);就诊时有呼吸道感染症状儿童202例,无呼吸道感染症状儿童1 540例。受检儿童的血清视黄醇中位水平0.29 mg/L(0.25~0.33 mg/L),有呼吸道感染症状儿童低于无呼吸道症状儿童,差异有统计学意义(P<0.001)。亚临床维生素A缺乏、可疑亚临床缺乏比例分别为5.8%和47.9%;<9岁儿童的亚临床及可疑亚临床缺乏比率均>50%,不同年龄组的亚临床和可疑亚临床缺乏比例的差异有统计学意义(P<0.001)。亚临床维生素A缺乏、可疑亚临床缺乏及正常组儿童的贫血发生率分别为3.9%、8.7%、10.8%,差异有统计学意义(P<0.01)。血清视黄醇、血红蛋白浓度与年龄均呈正相关(r=0.179、0.571,P均<0.001);血清视黄醇与血红蛋白浓度呈正相关(r=0.244,P<0.001)。结论呼吸道感染儿童血清视黄醇水平低于健康儿童,维生素A缺乏与贫血发生相关。Objectives To explore the nutritional status of vitamin A in healthy children and children with respiratory infection symptoms,and its correlation with hemoglobin levels.Methods Health children who lived in Beijing for over half year during December2014to August2015were included.Serum retinol and peripheral blood hemoglobin were measured.The relationship of vitamin A nutritional status with age,respiratory tract infection and anemia were analyzed.Results A total of1742children(1056males and686females)with a median age of3.1years(6months^17years)were enrolled.202children had respiratory tract infection and1540children didn’t have respiratory tract infection when visiting.The median serum retinol level was0.29mg/L(0.25~0.33mg/L)in all children.The level of retinol in children with respiratory tract symptoms was significantly lower than that in children without respiratory symptoms(P<0.001).The prevalence of subclinical vitamin A deficiency and suspected subclinical deficiency were5.8%and47.9%respectively.The prevalence of both the subclinical and suspected subclinical vitamin A deficiency ratios were>50%in children under9-year-old.The prevalence of subclinical vitamin A deficiency and suspected subclinical deficiency among different age groups were statistically different(P<0.001).The incidence of anemia in subclinical vitamin A deficiency,suspected subclinical deficiency children and normal children were3.9%,8.7%,and10.8%respectively,and The differences were statistically significant(P<0.01).Serum retinol and hemoglobin concentrations were positively correlated with age(r=0.179or0.571,P all<0.001).Furthermore,serum retinol was positively correlated with the concentration of hemoglobin(r=0.244,P<0.001).Conclusions Serum retinol level in children with respiratory infection is lower than that in healthy children.Vitamin A deficiency was associated with anemia.

关 键 词：维生素A 缺乏症 呼吸道感染 血红蛋白 

分 类 号：R723.2[医药卫生—儿科]