2-氨基-6-氯鸟嘌呤的合成工艺改进研究  

Improvement Study on the Synthesis Technology of 2-Amino-6-Chloropguanine

作　　者：应梦遥 李坚军 Ying Mengyao;Li Jianjun(National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients, College of Pharmaceutical Sciences,Zhejiang University of Technology, Hangzhou 310014)

机构地区：[1]浙江工业大学药学院国家化学原料药合成工程技术研究中心,杭州310014

出　　处：《化工生产与技术》2016年第5期30-31,45,共3页Chemical Production and Technology

摘　　要：研究了泛昔洛韦关键中间体2-氨基-6-氯鸟嘌呤的合成工艺,以鸟嘌呤为起始原料,双(三氯甲基)碳酸酯(BTC)为氯化剂进行氯化、水解反应合成目标产物2-氨基-6-氯鸟嘌呤。着重考察了反应溶剂、BTC用量和反应时间对氯化反应的影响,得到较优的工艺条件,总收率达到49%。该工艺操作简单、经济合理、环境友好,为2-氨基-6-氯鸟嘌呤的合成提供了一条新的具有潜在工业化价值的合成途径。The paper studied the synthesis technology of the key intermediate of famciclovir,2-amino-6-chloroguanine.The target product of2-amino-6-chloroguanine was obtained by the chlorination and hydrolysis reaction of guanine and bis-(trichloromethyl)carbonate(BTC)as chlorinating agent.We mainly discussed the factors of chlorination reaction such as reaction solvent,BTC consumption,and reaction time to get the better reaction conditions and the total yield was gotten in49%.This technology had advantages such as simple process,rationality economic and and environmentally friendly,it was a new pathway with potential industrial value to synthesis2-amino-6-chloroguanine.

关 键 词：2-氨基-6-氯鸟嘌呤 鸟嘌呤 双(三氯甲基)碳酸酯 氯化反应 

分 类 号：TQ460.4[化学工程—制药化工]