Analysis of penicillamine using Cu-modified graphene quantum dots synthesized from uric acid as single precursor  

作　　者：Gema M.Durán Tomás E.Benavidez Ana M.Contento Angel Ríos Carlos D.García 

机构地区：[1]Department of Analytical Chemistry and Food Technology, University of Castilla-La Mancha [2]IRICA (Regional Institute of Applied Scientific Research) [3]Department of Chemistry, Clemson University,219 Hunter Laboratories

出　　处：《Journal of Pharmaceutical Analysis》2017年第5期324-331,共8页药物分析学报（英文版）

基　　金：supported by the NIH–Research Centers at Minority Institutions (G12MD007591);the projects CTQ201678793-P (MINECO of Spain);PEIC-2014-001-P (Junta de Comunidades de Castilla-La Mancha, JCCM);MINECO of Spain for the predoctoral (BES-2011-045438);stay (EEBB-I-15-10091) grants

摘　　要：A simple methodology was developed to quantify penicillamine(PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots(Cu-GQDs). The proposed strategy combines the advantages of carbon dots(over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response(in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.A simple methodology was developed to quantify penicillamine(PA) in pharmaceutical samples, using the selective interaction of the drug with Cu-modified graphene quantum dots(Cu-GQDs). The proposed strategy combines the advantages of carbon dots(over other nanoparticles) with the high affinity of PA for the proposed Cu-GQDs, resulting in a significant and selective quenching effect. Under the optimum conditions for the interaction, a linear response(in the 0.10–7.50 μmol/L PA concentration range) was observed. The highly fluorescent GQDs used were synthesized using uric acid as single precursor and then characterized by high resolution transmission electron microscopy, Raman spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, fluorescence, and absorption spectroscopy. The proposed methodology could also be extended to other compounds, further expanding the applicability of GQDs.

关 键 词：GRAPHENE quantum DOTS ONE-STEP synthesis Fluorescence QUENCHING PENICILLAMINE PHARMACEUTICAL preparations 

分 类 号：R914[医药卫生—药物化学]