新福菌素胸腔灌注治疗非小细胞肺癌患者的效果及对患者血清免疫球蛋白的影响  

The Efficacy of Sinoactionomycin for Treatment of Patients with Non-small Cell Lung Cancer

作　　者：李洪伟 宋言峥 LI Hongwei;SONG Yanzheng(Department of Thoracic Surgery, Shanghai Public Health Clinical Center, Shanghai, 201508, China)

机构地区：[1]复旦大学附属公共卫生临床中心胸外科,上海201508

出　　处：《肿瘤药学》2017年第5期551-555,共5页Anti-Tumor Pharmacy

基　　金：复旦大学附属公共卫生临床中心基金项目(KSF0645)

摘　　要：目的探讨新福菌素胸腔灌注治疗非小细胞肺癌患者的效果及对患者血清免疫球蛋白的影响。方法选取我院2012年9月~2016年12月收治的非小细胞肺癌患者80例,随机分为观察组和对照组,每组40例。对照组采用GP方案进行化疗,观察组在GP方案的基础上给予新福菌素胸腔灌注,对比两组患者的胸腔积液治疗疗效,生存率和血清Ig A、Ig G、Ig M水平。结果胸腔积液治疗疗效方面,观察组CR 10例、PR 12例、SD 14例、PD 4例,RR为55%,高于对照组的35%,但差异无统计学意义(P>0.05);观察组1年、2年、3年生存率分别为80%、75%、75%,与对照组比较,差异无统计学意义(P>0.05),4年、5年生存率分别为70%、65%,明显高于对照组(P<0.05);治疗后两组患者血清Ig A、Ig G、Ig M水平明显升高,且观察组显著高于对照组(P<0.05)。结论新福菌素胸腔灌注治疗可以提高肺癌胸腔积液缓解率及肺癌的化疗敏感性,提高患者生存率,值得临床推广运用。Objective To investigate the efficacy of Actinomycin Injection for treatment of patients with non-small cell lung cancer andits effect on the serum immunoglobulin levels.Methods80patients with non-small cell lung cancer that accepted in our hospital from September2009to September2012were collected and divided into the observation group and control group(40cases in each group)respectively.Patients in the control group were treated with GP chemotherapy.Based on the routine treatment,patients in the observation groupwere given additional Actinomycin Injection pleural perfusion.The efficacy,survival rates,and serum immunoglobulin(IgA、IgG and IgM)levels were analyzed between the two groups.Results In the respect of the efficacy,the CR,PR,SD,PD and RR rate were10%,12%,14%,4%and55%in the observational groups,the difference has no significance compared with that in control group(35%);There were no significantdifferences in the survival rates between the patients in the two groups after operation1to3years,which were80%,75%and75%,respectively.However,the4-and5-year survival rates of the patients in observation group were70%and65%,significantly higher thanthat in control group(P<0.05),respectively.The immune globulin levels in the observation group were(3.76±1.25),(19.76±1.54)and(3.10±1.13),which was significantly higher than that in the control group(P<0.05).Conclusion The results show that the new method can improvethe remission rate of pleural effusion,the sensitivity of lung cancer chemotherapy,the immune status and the long-term survival rate ofpatients with lung cancer,which is worthy of clinical application.

关 键 词：新福菌素 胸腔积液 非小细胞肺癌 血清免疫球蛋白 

分 类 号：R734.2[医药卫生—肿瘤]