雷帕霉素在视网膜母细胞瘤婴幼儿患者中的应用及对预后的影响  

The Effect of Rapamycin on the Prognosis of Patients with Retinoblastoma

作　　者：单冬炜 经涛[1] 沈建华[2] 丁冬官 祝兵[3] 谢平[4] 于惠敏[5] SHAN Dongwei;JING Tao;SHEN Jianhua;DING Dongguan;ZHU Bing;XIE Ping;YU Huimin(Department of Ophthalmology,Dongtai People’s Hospital, Dongtai,Jiangsu, 224200, China;Department of Neurosurgery,Dongtai People’s Hospital, Dongtai,Jiangsu, 224200, China;Department of Anesthesia, Dongtai People’s Hospital, Dongtai,Jiangsu, 224200, China;Jiangsu Province People’s Hospital of Ophthalmology, Nanjing, Jiangsu, 210029, China;Department of Ophthalmology, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013, China)

机构地区：[1]东台市人民医院眼科,江苏东台224200 [2]东台市人民医院神经外科,江苏东台224200 [3]东台市人民医院麻醉科,江苏东台224200 [4]江苏省人民医院眼科,江苏南京210029 [5]中南大学湘雅三医院眼科,湖南长沙410013

出　　处：《肿瘤药学》2017年第5期605-609,共5页Anti-Tumor Pharmacy

摘　　要：目的探讨雷帕霉素在视网膜母细胞瘤婴幼儿患者中的应用及对治疗预后的影响。方法选取60例视网膜母细胞瘤婴幼儿患者,随机为两组,对照组30例,采用局部治疗及化疗,研究组30例,在对照组的基础上联合应用雷帕霉素治疗。比较两组患儿的近期疗效,外周血T、B淋巴细胞亚群及不良反应。结果近期疗效方面,研究组患儿的有效率以及控制率均显著高于对照组(P<0.05);治疗前两组患儿CD4+、CD8+、CD3+CD56+以及CD4+CD25+等指标比较,差异无统计学意义(P>0.05),治疗后均获得一定程度的改善,且研究组患儿改善程度显著优于对照组(P<0.05);两组患儿的不良反应发生率比较,差异无统计学意义(P>0.05)。结论在局部治疗以及化疗的基础上联合应用雷帕霉素治疗视网膜母细胞瘤婴幼儿患者,可提高近期疗效,并改善患儿预后。Objective To investigate the effect of rapamycin on the prognosis of patients with retinoblastoma.Methods60retinoblastomapatients were randomly divided into two groups,the patients in control group were treated with local treatment and chemotherapy,andpatients in study group was treated with rapamycin on the basis of local treatment and chemotherapy.Results The effective rate and the vacancyrate of patients for short-term efficacy in study group with is higher than that in control group(P<0.05);there was no significant differencein CD4+,CD8+,CD3+CD56+,CD4+CD25+indexes before treatment between the two groups(P>0.05),but they all improved to someextent after the treatment,the improvement in study group was better than that in control group(P<0.05);there was no significant differencein adverse reactions between the two groups(P>0.05).Conclusion Rapamycin combined with local treatment and chemotherapy can improvethe prognosis of patients with retinoblastoma.

关 键 词：雷帕霉素 视网膜母细胞瘤 局部治疗 化疗 预后 

分 类 号：R739.7[医药卫生—肿瘤]