不同剂量咪达唑仑诱导在肺癌患者手术中的效果评估  

Effect Evaluation of Midazolam Induction at Different Doses in Operation of Patients with Lung Cancer

作　　者：薛婷如 孙鸿然 李书涛[1] 肖峰[1] 王贤裕[1] XUE Tingru;SUN Hongran;LI Shutao;XIAO Feng;WANG Xianyu(Department of Anesthesiology, Taihe Hospital of Hubei Medical College, Shiyan, Hubei, 442000, China;Chongqing Medical University, Chongqing, 400016, China)

机构地区：[1]湖北医药学院附属太和医院麻醉科,湖北十堰442000 [2]重庆医科大学,重庆400016

出　　处：《肿瘤药学》2017年第5期610-613,共4页Anti-Tumor Pharmacy

摘　　要：目的探讨不同剂量咪达唑仑诱导在肺癌患者手术中的对比及对患者认知功能的影响。方法选取2016年5月~2017年5月在我院接受手术治疗的肺癌患者116例,随机分为两组,各58例。对照组患者手术期应用小剂量咪达唑仑诱导干预治疗,研究组手术期应用大剂量咪达唑仑进行干预治疗。对比两组患者苏醒时各项体征、MMSE评分及炎症因子水平变化。结果研究组患者睁眼时间、拔管时间、VAS评分、SAS评分均明显优于对照组患者(P<0.05);干预前两组患者MMSE评分无明显差异(P>0.05),干预后研究组患者MMSE评分明显优于对照组患者(P<0.05);干预前两组患者炎症因子水平无明显差异,干预后研究组患者炎症因子水平明显优于对照组(P<0.05)。结论肺癌患者手术过程中联合使用适合剂量的咪达唑仑辅助诱导麻醉安全可靠,患者术后认知障碍情况得到有效缓解,可进一步推广应用于临床。Objective To explore effect evaluation of midazolam induction at different doses in operation of patients with lung cancer.Methods116lung cancer patients with surgical treatment in our hospital were randomly divided into two groups from May2016to May2017.The patients in control group were given preoperative use of low-dose midazolam induction intervention,while,the patients in researchgroup were given preoperative use of large dose of midazolam intervention treatment.The changes of various signs,MMSE scores,and inflammatory factors were compared between the two groups.Results The opening eye time,extubation time,VAS score,and SAS scoreof patients in the research group were significantly better than those in the control group(P>0.05).There was no significant difference inMMSE scores between the two groups(P<0.05),and MMSE score of patients in the research group after intervention was significantly betterthan that in the control group(P<0.05).There was no significant difference in the levels of inflammatory factors between the two groupsbefore intervention,and the level of the validation factor in research group was significantly better than that in the control group(P<0.05).Conclusion Using the appropriate auxiliary midazolam induction of anesthesia is not only safe for treatment of patients with lung cancer insurgery process,but also it can effectively relieve postoperative cognitive dysfunction of patients.It should be for further clinical application.

关 键 词：不同剂量 咪达唑仑 诱导 肺癌手术 认知功能 

分 类 号：R734.2[医药卫生—肿瘤]