骨关节炎小动物模型的制备及量表评价  

Establishment and assessment of small animal models of osteoarthritis

作　　者：吴伟[1] 李慧 邹军[1] 王淼[1] Wu Wei;Li Hui;Zou Jun;Wang Miao(Shanghai University of Sport, Shanghai 200438, China)

机构地区：[1]上海体育学院,上海市200438

出　　处：《中国组织工程研究》2017年第28期4529-4535,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81572242);上海市人类运动能力开发与保障重点实验室(上海体育学院)资助(11DZ2261100)~~

摘　　要：背景:骨关节炎动物模型对研究骨关节炎的发病机制及防治具有重要意义,国内外建立模型的方式有许多,不同的建模方式都在一定程度上模拟了人类骨关节炎的发展。临床研究中,骨关节炎的发生发展受到一定刺激因子的影响。目的:综述近年国内外骨关节炎模型的研究进展,评价近几年小动物造模方法和影响骨关节炎发生发展的刺激因子。方法:应用计算机检索至2016年12月PubMed数据库、中国期刊全文数据库相关文章,英文检索词为:"Osteoarthritis,animal models,stimulating factors,assessment grading system,outcome measurement";中文检索词为:"骨关节炎,动物模型,刺激因子,评价量表,结局指标"。最终纳入57篇文章进行综述。结果与结论:(1)近几年骨关节炎模型以关节内手术(破坏交叉韧带及半月板)居多,Mankin评价量表应用较为广泛,实验动物年龄偏小;(2)骨关节炎应选择骨生长发育成熟的小动物模型,避免生长因素对骨关节炎产生自愈干扰。BACKGROUND:Animal models of osteoarthritis are of great significance for the studies on its pathogenesis,prevention and treatment.There are various osteoarthritis models that certainly simulate the development of human osteoarthritis.Some stimulating factors have been found to participate in the occurrence and development of osteoarthritis.OBJECTIVE:To review the recent researches about animal models of osteoarthritis at home and abroad,and to assess different modeling methods and some stimulating factors related to the occurrence and development of osteoarthritis.METHODS:A computer-based retrieval of CNKI and PubMed databases before December2016was performed with the keywords of“osteoarthritis,animal models,stimulating factors,assessment grading system,outcome measurement”in Chinese and English,respectively.Finally57eligible papers were included for analysis.RESULTS AND CONCLUSION:(1)In recent years,the osteoarthritis models are mainly established by doing damage to the cruciate ligaments and meniscus,and evaluated by Mankin score;the age of experimental animals tend to be younger.(2)Animals developed maturely are rational,so as to avoid the effect of self-healing caused by growth factors on osteoarthritis occurrence.

关 键 词：组织构建 骨组织工程 骨关节炎 小动物模型 刺激因子 评价量表 结局指标 国家自然科学基金 

分 类 号：R318[医药卫生—生物医学工程]