同步放化疗与单纯放疗在宫颈浸润癌的近期疗效及安全性  

Comparison of Efficacy and Safety of Concurrent Radiotherapy and Chemotherapy in Treatment of Invasive Carcinoma of Cervix

作　　者：陈洪志[1,2] 康华峰 易春曦[3] 杨乐[1] CHEN Hong-zhi;KANG Hua-feng;YI Chun-xi;YANG Le(Dept. of Oncology,Xi’an Central Hospital,Xi’an 710003, Shaanxi;Dept. of Oncology,The Second Affiliated Hospital of Xi’an Jiao Tong University,Xi’an 710004,Shaanxi;Dept. of Otolaryngoloy-Head & Neck Surgery,Xi’an Central Hospital,Xi’an 710003,Shaanxi)

机构地区：[1]西安市中心医院肿瘤科,陕西西安710003 [2]西安交通大学第二附属医院肿瘤科,陕西西安710004 [3]西安市中心医院耳鼻喉科,陕西西安710003

出　　处：《昆明医科大学学报》2017年第4期68-71,共4页Journal of Kunming Medical University

基　　金：陕西省自然科学基金资助项目(2014JM2-8182)

摘　　要：目的观察同步放化疗治疗宫颈浸润癌的近期疗效及安全性,探讨其临床价值.方法选择西安市中心医院于2013年1月至2015年3月收治的符合宫颈浸润癌诊断标准患者86例入选本研究,按照数字随机分为2组,每组43例.单纯组术前采取单纯放疗治疗,腔内半量放疗,每次7 Gy,1次/周,总剂量21 Gy×3次;联合组术前采取联合放化疗治疗,腔内剂量21 Gy×3次;顺铂20 mg/m^2,放疗第1天开始静滴,连续5 d.2组均于疗程结束2周后行手术治疗,比较2组疗效.结果联合组有效率39例(90.7%),高于单纯组31例(72.1%),P<0.05.联合组宫旁浸润及淋巴结阳性率均低于单纯组,P<0.05.2组治疗期间白细胞降低、恶心、呕吐、腹泻及肝肾功能异常发生率比较差异无统计学意义(P>0.05);联合组脱发21例(48.8%),高于单纯组0例(0.0%),P<0.05.结论同步放化疗治疗宫颈浸润癌的近期疗效较佳,宫旁浸润及淋巴结阳性率更低,但脱发发生率更高,具有重要临床价值.Objective To observe the safety and efficacy of concurrent radiotherapy and chemotherapy in thetreatment of invasive carcinoma of cervix,and to evaluate its clinical value.Methods We selected86patientstreated in our hospital in January2013-2015year in March according to the diagnostic criteria of invasive cervicalcancer in this study,and randomly divided them into two groups,with43cases in each group.The simple group wasgiven single radiotherapy before operation,including half amount of radiotherapy in the the cavity,7Gy each time,1time/week,total dose of21Gy*3times.The combined group was given preoperative radiotherapy andchemotherapy,including21Gy*3times of radiotherapy,and intravenous instillation of20mg/m2of cisplatin forcontinuous5days form the first day of radiotherapy.Patients in both groups were given surgical treatment2weeksafter single radiotherapy or combined radiotherapy and chemotherapy,then the curative effects of two groups werecompared.Results The effective rate of combined group was90.7%(39cases)and was higher than that of simplegroup72.1%(31cases)(P<0.05).The parametrial invasion and lymph node positive rate in the combinedgroup was lower than that in the simple group(P<0.05).There was no statistically significant difference in thewhite blood cell decrease,the incidence of nausea,vomiting,diarrhea and abnormal liver and kidney function between two groups(P>0.05).The hair loss rate in the combined group was48.8%(21cases),which washigher than the simple group(0%)(P<0.05).Conclusion Concurrent chemotherapy in the treatment ofcervical cancer infiltration is better,the infiltration and lymph node positive rate is lower,but the incidence of hairloss is higher,so it has important clinical value.

关 键 词：同步放化疗 宫颈癌 近期疗效 淋巴结 

分 类 号：R737.33[医药卫生—肿瘤]