DRD2和DRD3基因多态性与利培酮治疗精神分裂症疗效的关联性  

Association between DRD2, DRD3 Gene Polymorphisms and Clinical Response to Risperidone Treatment in Chinese Han Schizophrenia Patients

作　　者：冯国华[1] 卫芋君 元静[1] 张艳[1] 曾雷[1] 杨建中[1] FENG Guo-hua;WEI Yu-jun;YUAN Jing;ZHANG Yan;ZENG Lei;YANG Jian-zhong(Dept. of Psychiatry,The Second Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院精神科,云南昆明650101

出　　处：《昆明医科大学学报》2017年第5期50-55,共6页Journal of Kunming Medical University

基　　金：国家自然科学基金地区基金项目(81160170);云南省卫生厅卫生系统学科带头人培养经费资助项目(D-201237)

摘　　要：目的探讨DRD2和DRD3基因多态性与利培酮治疗精神分裂症临床疗效间的关系.方法共106例中国西南地区汉族精神分裂症患者接受单一利培酮治疗12周,应用阴性和阳性症状量表(Positive and Negative Syndrome Scale,PANSS)、个人和社会功能量表(Personal and Social Performance Scale,PSP)、瑞文标准推理测验、韦氏智能测验数字识记法、数字划消测验分别对患者进行基线和12周末的测评,同时收集同一地区汉族健康对照178例;采用Taq Man等位基因分型方法对DRD2和DRD3基因的3个多态性位点(rs1800496,rs6276,rs6280)进行基因分型,SHEsis在线软件来检测Hardy-Weinberg平衡、基因型和等位基因频率分析.采用SPSS17.0统计软件包进行统计分析.结果 (1)rs1800496对照组和实验组均为单一基因型AG,未见纯合子,不是基因多态性位点;(2)精神分裂症组与对照组在2个多态性位点的基因型分布和等位基因频率上均无统计学差异(P>0.05);(3)治疗前,DRD2基因rs6276三种基因型患者在基线PANSS阴性症状得分上的差异具有统计学意义(P=0.007).治疗后,DRD2基因rs6276三种基因型在治疗前后PANSS阴性症状得分差值(P=0.002)以及PSP总分差值上的差异具有统计学意义(P=0.024).结论利培酮治疗精神分裂症疗效显著,对部分认知功能有改善作用,DRD2基因的rs6276多态性可能与利培酮治疗精神分裂症阴性症状的改善有关系,DRD3基因的rs6280多态性可能与利培酮治疗精神分裂症的疗效无关.Objective To investigate the relationship between the polymorphisms of DRD2,DRD3gene andclinical efficacy of risperidone in schizophrenia.Methods106schizophrenia patients of Han Chinese in southwestChina were recruited and completed12weeks of treatment with risperidone monotherapy.Positive and NegativeSyndrome Scale(PANSS),Personal and Social Performance Scale(PSP),Digit Span Test in WechslerIntelligence Scale,Raven's Standard Progressive Matrices,Digital Cancellation Test were used to assess patients'psychotic symptoms and cognitive function at baseline and weekend of12.178Han healthy controls in the same areawere also collected.We genotyped3SNPs(rs1800496,rs6276,rs6280)in DRD2and DRD3by using TaqManSNP Genotyping Assays.SHEsis online software were used to detect the Hardy-Weinberg equilibrium,genotypeand allele frequency.SPSS17.0statistical package was used for statistical analysis.Results1.Rs1800496was foundonly one genotype AG,without homozygous in the schizophrenia and control groups,suggesting not a polymorphic site.2.Schizophrenia and control groups were not statistically different in genotype distributions and allele frequenciesof two polymorphic sites(P>0.05).3.At baseline,three genotypes of rs6276in DRD2in patients werestatistically different for the baseline PANSS negative symptom score(P=0.007).After the treatment of12weeks,three genotypes of rs6276in patients were statistically different in the PANSS negative symptom score change(P=0.002)and PSP total score change(P=0.024).Conclusions Risperidone treatment has good clinical response inschizophrenia patients,especially for the cognitive function.The rs6276polymorphism of DRD2gene may beassociated with the baseline negative symptoms and clinical improvement of negative symptoms to risperidonetreatment in schizophrenia.The rs6280in DRD3gene may be not assosiated with the effect of risperdone in thetreatment of schizophrenia

关 键 词：DRD2 DRD3 精神分裂症 利培酮 疗效 

分 类 号：R749.3[医药卫生—神经病学与精神病学]