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作 者:李蓝江[1] 许冰莹[1] 杨春艳[1] 赵川[1] 田心[1] LI Lan-jiang;XU Bing-ying;YANG Chun-yan;ZHAO Chuan;TIAN xin(Kunming Medical University,Kunming Yunnan 650500,China)
机构地区:[1]昆明医科大学,云南昆明650500
出 处:《昆明医科大学学报》2017年第7期73-75,共3页Journal of Kunming Medical University
基 金:云南省应用基础研究计划项目(2011FZ103)
摘 要:目的探讨基质金属蛋白酶(MMP)1基因多态性与云南汉族口腔鳞癌发病风险的相关性,为临床上口腔鳞癌易感基因的发现与筛选提供实验参考.方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法,检测口腔鳞癌患者与健康对照组个体的MMP1启动子-1607 1G/2G单核苷酸多态性(SNP),获得口腔鳞癌患者的基因型,与健康对照组进行比较.结果 MMP1基因型在口腔鳞癌病例组和健康对照组的分布:健康对照组和病例组在MMP1启动子-1607 1G/2G中1G/1G、2G/2G、1G/2G的基因型频率分别为11.11%、37.04%、51.85%和5.66%、43.40%、50.94%.MMP1SNP与口腔鳞癌发病风险比较差异无统计学意义(P>0.05),分别与高、中、低分化口腔鳞癌发病风险比较差异无统计学意义(P>0.05).结论 MMP1启动子-1607 1G/2G SNP可能与云南汉族口腔鳞癌发病风险无相关性.Objective To explore the correlation between MMP1gene polymorphisms and risk of oral squamous cell carcinomas among Han nationality in Yunnan province and to provide experimental reference for discovery and screening of susceptibility genes of oral squamous carcinoma.Methods Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)was applied to detect individual MMP1promoter-16071G/2G loci single nucleotide polymorphisms(SNP)in patients with oral squamous cell carcinomas and control group.The genotype of the patients with oral squamous carcinoma was obtained and compared with that in the control group.Results The genotype frequencies of MMP1promoter-16071G/2G,1G/1G,2G/2G,1G/2G were11.11%and37.04%,51.85%and5.66%,43.40%and50.94%in control group and case group respectively.There was no significant difference between MMP1SNP and the risk of oral squamous cell carcinomas(P>0.05).No significant difference was found when MMP1SNP was compared with high,medium and low differentiation of oral squamous cell carcinomas(P>0.05).Conclusion There is no correlation between MMP1promoter-16071G/2G loci SNP and the risk of oral squamous carcinoma among Han nationality in Yunnan province.
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