IL-17、IL-23在接受利妥昔单抗治疗的B细胞非霍奇金淋巴瘤患者中的表达  

The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP

作　　者：黄颖[1] 刘熠晗 黎承平[1] 武坤[1] 曾云[1] HUANG Ying;LIU Yi-han;LI Cheng-ping;WU Kun;ZENG Yun(Dept. of Hematology,The 1st Affiliated Hospital,Kunming Medicine University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一附属医院血液科,云南昆明650032

出　　处：《昆明医科大学学报》2017年第8期67-72,共6页Journal of Kunming Medical University

基　　金：云南省教育厅科学研究基金资助项目(2013Y292)

摘　　要：目的检测B细胞非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)患者治疗前后IL-17、IL-23表达水平的变化,探讨IL-17、IL-23在NHL发生发展过程中的作用.方法应用逆转录-聚合酶链式反应(reverse transcription-polymerase chain reaction,RT-PCR)法检测25例接受标准剂量R-CHOP方治疗6~8个疗程的B细胞NHL患者和20例健康对照组.结果 NHL患者初诊时和缓解时外周血中IL-17m RNA的表达水平均低于健康对照组(P<0.05).NHL患者缓解时与初诊时相比,IL-17m RNA的表达水平有所升高(P<0.05).NHL患者初诊时和缓解时外周血中IL-23m RNA的表达水平均低于健康对照组(P<0.05).缓解时与初诊时相比,IL-23m RNA的表达水平升高(P<0.05).结论 B细胞非霍奇金淋巴瘤患者接受利妥昔单抗治疗后IL-17、IL-23水平升高.IL-17、IL-23m RNA的表达与预后相关.Objectives To detect the expression levels ofIL-17and IL-23in peripheral blood of B-cell non-Hodgkin lymphoma patients treated by RCHOP and to study the role of IL-17and IL-23in NHL.Methods Twenty-five patients with B-cell NHL who achieved remission after6to8cycles of R-CHOP as a NHL group,20healthy volunteers were recruited as a normal control group.RT-PCR was used to detect the expression levels of IL-17mRNA and IL-23mRNA in NHL patients and health volunteers.Results The expression levels of IL-17mRNA andIL-23mRNA in the patients with NHL before therapy and the patients with NHL who achieved remission were lower than that in the normal control group(P<0.05).The expression levels of IL-17mRNA andIL-23mRNA in the patients with NHL who achieved remission were higher than that in the patients with NHL before therapy(P=0.001,P<0.05).Conclusions IL-17and IL-23mRNA levels are higher after treated with R-CHOP.The expression levels of IL-17mRNA and IL-23mRNA in NHL patients are related with prognosis and efficacy.

关 键 词：非霍奇金淋巴瘤 白介素-17 白介素-23 利妥昔单抗 预后 

分 类 号：R733.1[医药卫生—肿瘤]