TACE联合利卡汀治疗对肝癌患者病理指标及CTCs检出数的影响  

Effect of transcatheter arterial chemoembolization combined with Licartin on pathological indicators and number of circulating tumor cells in liver cancer patients

作　　者：吴润芝 张为群 王信成 程庆保[2] Run-zhi Wu;Wei-qun Zhang;Xin-cheng Wang;Qing-bao Cheng(Department of General Surgery, Shuyang Zhongshan Hospital, Shuyang, Jiangsu 223600, China;Eastern hepatobiliary surgery Hospital, Shanghai 200438, China)

机构地区：[1]江苏省沭阳中山医院普外科,江苏沭阳223600 [2]上海东方肝胆外科医院胆道一科,上海200438

出　　处：《中国现代医学杂志》2017年第28期29-35,共7页China Journal of Modern Medicine

基　　金：上海市科学技术委员会科技发展基金(No:12211967700)

摘　　要：目的探讨经导管肝动脉化疗栓塞术(TACE)联合利卡汀治疗对肝癌患者病理指标及循环肿瘤细胞(CTCs)检出数的影响。方法选取2014年1月-2016年6月在沭阳中山医院介入科接受治疗的120例原发性肝癌患者作为该研究对象。根据患者治疗意愿将其分为对照组和实验组,其中对照组52例,仅给予经导管肝动脉化疗栓塞术治疗,实验组68例,在对照组治疗基础上联合利卡汀治疗。比较两组患者治疗前后肿块大小、甲胎蛋白(AFP)水平、血象、肝功能、CTCs以及CD147不同分子表型患者。结果治疗后两组患者肿瘤大小相比差异无统计学意义(P>0.05);治疗后,两组AFP水平比较,差异有统计学意义(P<0.05),实验组低于对照组;治疗后,两组白细胞计数和丙氨酸转氨酶比较,差异有统计学意义(P<0.05),白细胞计数实验组低于对照组,丙氨酸转氨酶实验组高于对照组;治疗后两组CTCs检出数目比较,差异有统计学意义(P<0.05),均降低,且实验组低于对照组;实验组CD147 2种表型患者治疗前后CTCs数目变化值间比较,差异有统计学意义(P<0.05);对照组CD147 2种表型患者治疗前后CTCs数目变化值间比较,差异无统计学意义(P>0.05);两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论利卡汀联合TACE治疗肝癌,临床效果优于单纯TACE治疗,此外,利卡汀对于CD147^+肝癌患者治疗效果优于CD147^-患者。Objective To explore the effect of transcatheter arterial chemoembolization(TACE)combinedwith Licartin on pathological indicators and number of circulating tumor cells(CTCs)in liver cancerpatients.Methods Totally120cases of primary liver cancer patients treated in our hospital from January2014toJune2016were enrolled as research objects.They were divided into experimental group and control group accordingto treatment.The52cases in the control group were treated with TACE and the68cases in the experimental groupwere treated with Licartin and TACE.The tumor size,AFP level,blood routine,liver function,number of CTCs andnumber of CTCs in patients with different molecular phenotypes of CD147were compared before and after treatmentbetween the two groups.Results After treatment,the tumor size of the two groups had no significant difference(P>0.05).After treatment,the AFP level significantly decreased in both groups,and was significantly lower in theexperimental group than in the control group(P<0.05).After treatment,the platelet count in the experimental groupwas significantly lower than that in the control group and alanine aminotransferase was significantly higher than thatin the control group(P<0.05).After treatment,the number of CTCs detected in the two groups was significantlydecreased,and the number of CTCs in the experimental group was significantly smaller than that in the control group(P<0.05).The changes of the number of CTCs before and after treatment had significant difference between thepatients with two different CD147phenotypes in the experimental group(P<0.05),while there was no significantdifference in the control group(P>0.05).There were no statistical differences in the incidences of adverse reactionsbetween the two groups(P>0.05).Conclusions For the treatment of liver cancer patients,Licartin combined withTACE has better clinical effect than TACE treatment.Licartin would be suggested for CD147+HCC patients,but notfor CD147-patients.

关 键 词：循环肿瘤细胞 肝癌 CD147分子表型 利卡汀 经导管肝动脉化疗栓塞术 

分 类 号：R735.3[医药卫生—肿瘤]