长链非编码RNA与乳腺癌  

Long Non-Coding RNA and Breast Cancer

作　　者：粟薇 张竹君[2] SU Wei;ZHANG Zhu-Jun(Beibei Maternal and Child Health Hospital, Chongqing, 400700,China;First Affiliated Hospital of the Third Military Medical University, Chongqing 400038,China)

机构地区：[1]重庆市北碚区妇幼保健院,重庆400700 [2]第三军医大学第一附属医院,重庆400038

出　　处：《生物技术通讯》2017年第6期860-864,共5页Letters in Biotechnology

基　　金：西南医院科技创新项目(SWH2016JCYB-12)

摘　　要：在肿瘤发生发展过程中,长链非编码RNA(lncRNA)通过在转录、转录后和表观遗传水平调节靶基因表达而发挥重要作用。在乳腺癌的研究中,大部分lncRNA表现为促癌因子,少部分表现为抑癌因子。lncRNA参与乳腺癌细胞增殖、凋亡、迁移、侵袭和肿瘤干细胞性维持的调控。深入研究lncRNA的作用和分子机制,将为乳腺癌的诊断和治疗提供新靶点和新思路。Long non-coding RNAs(lncRNAs)are involved in tumor progression by regulating gene expression at epigenetic,transcriptional and post-transcriptional levels.In breast cancer,several lncRNAs are identified as tumor driving oncogenic lncRNAs and few are identified as tumor suppressive lncRNAs.They are involved in cell growth,apoptosis,migration and invasiveness as well as cancer cell stemness maintenance.LncRNAs maybe an new target for breast cancer diagnosis and treatment.

关 键 词：长链非编码RNA 乳腺癌 分子机制 

分 类 号：R735[医药卫生—肿瘤]