VEGF和CYP1A1在非小细胞肺癌组织中的表达与临床意义  

Expressions and clinical significance of VEGF and CYP1A1in non-mall cell lung cancer

作　　者：池涛 常福厚 高峰[2,3] 王敏杰[4] 白图雅 吕晓丽 胡玉霞 CHI Tao;CHANG Fu-hou;GAO Feng;WANG Min-jie;BAI Tu-ya;LV Xiao-Li;HU Yu-xia(Department of Pharmacology, College of Pharmacy, Inner Mongolia Medical University, Hohhot 010110, China;The Center for New Drug Safety Evaluation and research of Inner Mongolia Medical University, Hohhot 010110, China;Inner Mongolia Autonomous Region Engineering Research Center of New Pharmaceutical Screening, Hohhot 010110, China;School of Basic Medical College, Inner Mongolia Medical University,Hohhot 010110, China)

机构地区：[1]内蒙古医科大学药学院,内蒙古呼和浩特010110 [2]内蒙古医科大学新药安全评价研究中心,内蒙古呼和浩特010110 [3]内蒙古自治区新药筛选工程研究中心,内蒙古呼和浩特010110 [4]内蒙古医科大学基础医学院,内蒙古呼和浩特010110

出　　处：《中国生化药物杂志》2017年第11期32-34,38,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：国家自然科学基金(81260499,81760676);内蒙古自治区自然科学基金(2015ms08189)

摘　　要：目的探讨血管内皮生长因子（vascularendothelialgrowthfactor，VEGF）和细胞色素P4501A1（cytochromeP4501A1，CYP1A1）与肺癌的发生、发展的关系。方法采用MaxVision免疫组化的方法检测58例肺癌组织及16例癌旁正常组织中，VEGF、CYP1A1蛋白的表达差异。结果免疫组化结果显示：与癌旁正常组织相比，肺癌组织VEGF、CYP1A1阳性表达率均存在统计学差异（P＜0.05）；Ⅰ、Ⅱ期的阳性表达率与Ⅲ、Ⅳ期相比，CYP1A1、VEGF蛋白表达均存在统计学差异（P＜0.05）。CYP1A1、VEGF蛋白表达的相关系数r为0.723。结论VEGF和CYP1A可能与肿瘤的发生发展有关，两个蛋白之间的表达可能存在一定关联且为正相关。Objective To explore the relationship between VEGF and CYP1A1and the development and progression of lung cancer.Methods58cases of lung cancer tissue and16cases of normal tissue were detected by Max vision immunohistochemistry.Results Immunohistochemistry results show:compared with adjacent normal group,there was significant difference in the positive rate ofCYP1A1and VEGF in lung cancer group(P<0.05).The positive expression rates of CYP1A1and VEGF were significantly different between stage I,II andIII,IV(P<0.05).The correlation coefficient of VEGF and CYP1A1was0.723.Conclusion VEGF and CYP1A may be associated with the occurrence and development of tumor.Correlation coefficient indicated the positive correlation between VEGF and CYP1A1expression

关 键 词：VEGF CYP1A1 免疫组化 肺癌 蛋白表达 

分 类 号：R734.2[医药卫生—肿瘤]