氨甲环酸在急性非静脉曲张性上消化道出血中的疗效评价  

Clinical evaluation of tranexamic acid in patients with acute nonvariceal upper gastrointestinal bleeding

作　　者：陆丽娜 蒋国法 黄伟 LU Li-na;JIANG Guo-fa;HUANG Wei(Digestion Medicine, Jinhua Grace Hospital, Jinhua 321000, China)

机构地区：[1]金华文荣医院消化内科,浙江金华321000

出　　处：《中国生化药物杂志》2017年第11期41-42,共2页Chinese Journal of Biochemical Pharmaceutics

基　　金：金华市科技计划社发类重点资助项目(2017-3-024)

摘　　要：目的分析氨甲环酸在急性非静脉曲张性上消化道出血中的疗效。方法选取金华文荣医院收治的86例急性非静脉曲张性上消化道出血患者为研究对象，随机分为对照组和实验组各43例。对照组给予埃索美拉唑，静脉使用。实验组在此基础上给予氨甲环酸，静脉滴注。比较分析2组患者的临床疗效、输血量及相关并发症发生情况。结果经过对应治疗后，实验组治疗有效率为86.04%，高于对照组有效率（83.72%），2组比较差异无统计学意义。实验组与对照组患者人均输血量分别为（402.12±134.20）mL与（403.33±135.44）mL，2组比较差异无统计学意义。实验组患者发生心绞痛及短暂脑缺血发作的概率为11.63%，高于对照组（0%），2组比较差异具有统计学意义（P＜0.05）。结论氨甲环酸在急性非静脉曲张性上消化道出血中的疗效并不理想，且可能增加心绞痛及短暂脑缺血等并发症发生概率。Objective To study the analysis of tranexamic acid in patients with acute non variceal upper gastrointestinal bleeding in clinical evaluation.Methods86patients with acute non variceal upper gastrointestinal bleeding in Jinhua Grace Hospital were selected as the subjects.The control group was given intravenous esomeprazole.The experimental group was given intravenous drip of tranexamic acid.The clinical efficacy,blood transfusion and related complications of the experimental group and the control group were compared and analyzed.Results After the corresponding treatment,the effective rate was86.04%in the experimental group and83.72%in the control group.The difference between the two groups was not statistically significant.The blood transfusion volume of the patients in the experimental group and the control group was(402.12±134.20)mL and(403.33±135.44)mL,respectively,and there was no statistical significance.In the experimental group,the incidence of angina pectoris and transient ischemic attack was11.63%,significantly higher than that of the control group(0%),with statistical difference(P<0.05).Conclusion Tranexamic acid in patients with acute nonvariceal upper gastrointestinal hemorrhage in is not ideal,and may increase the angina pectoris and transient ischemic complications such as probability.

关 键 词：氨甲环酸 抗纤溶剂 上消化道出血 静脉曲张 

分 类 号：R573.2[医药卫生—消化系统]